Development of docetaxel-loaded vitamin E TPGS micelles: formulation optimization, effects on brain cancer cells and biodistribution in rats

Nanomedicine
Madaswamy S MuthuSi-Shen Feng

Abstract

This work aimed to develop docetaxel-loaded D-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS or TPGS) micelles for brain cancer chemotherapy by taking advantage of polyethylene glycol for its long half-life in circulation and vitamin E for its high cellular uptake. TPGS micelles containing docetaxel or coumarin-6 were prepared by the solvent casting method and the direct dissolution method at high, moderate and low drug-loading levels. The particle size of the docetaxel-loaded TPGS micelles ranged between 12 and 14 nm. Docetaxel formulated in the TPGS micelles of high, moderate and low drug-loading levels achieved lower IC(50) values compared with Taxotere after 24-h incubation with C6 glioma brain cancer cells. The TPGS has much lower critical micelle concentration than most phospholipids in micellar formulation, which can be an efficient drug carrier across the blood brain-barrier with high drug encapsulation efficiency, cell uptake, cytotoxicity and desired biodistribution of the formulated drug.

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Citations

Nov 15, 2012·Nanomedicine·Madaswamy S Muthu
Mar 19, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nicolas DuhemVéronique Préat
Nov 19, 2014·Nanomedicine·Chor Yong Tay, David Tai Leong
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Yanbin SunShun Xu
Jan 23, 2016·International Journal of Pharmaceutics·Bingyang ChuZhiyong Qian
Mar 6, 2013·Expert Opinion on Drug Delivery·Anandhkumar RajuSi-Shen Feng
Jun 19, 2012·Expert Opinion on Drug Delivery·Qi TanGuangxi Zhai
Feb 20, 2016·Colloids and Surfaces. B, Biointerfaces·Rahul Pratap SinghMadaswamy S Muthu
Dec 15, 2015·International Journal of Biological Macromolecules·Rahul Pratap SinghMadaswamy S Muthu
Sep 24, 2014·International Journal of Pharmaceutics·Fabienne DanhierVéronique Préat
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Rahul Pratap SinghMadaswamy S Muthu
Aug 9, 2016·Colloids and Surfaces. B, Biointerfaces· SonaliMadaswamy S Muthu
Jan 24, 2017·International Journal of Biological Macromolecules·Shazia TabasumKhalid Mahmood Zia
Jan 16, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Atmaram PawarC Bothiraja
Jun 7, 2019·Drug Development and Industrial Pharmacy·Yongshun SunZhiying Zhao
Dec 18, 2018·Pharmaceutical Development and Technology·Lijun ZhenJiangnan Yu
Oct 28, 2019·Therapeutic Delivery·Matte Kasi ViswanadhMadaswamy S Muthu
Oct 30, 2018·Nano Research·Yang LuZhiqiang Cao
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Jan 11, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sobiya ZafarFarhan Jalees Ahmad
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Roshan SonkarMadaswamy S Muthu
Apr 30, 2021·International Journal of Pharmaceutics·Matte Kasi ViswanadhMadaswamy S Muthu
Jun 1, 2021·Archives of Biochemistry and Biophysics·Supriyo BeraPinak Chakrabarti

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Methods Mentioned

BETA
chemical modification
transmission electron microscopy
atomic force microscopy
AFM

Software Mentioned

NIS
Nanoscope
Element AR

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