Development of dopamine innervation and turning behavior in dopamine-depleted infant rats receiving unilateral nigral transplants

Neuroscience
A M Snyder-KellerR D Lund

Abstract

Three-day-old rats were bilaterally dopamine-depleted with 6-hydroxydopamine and 3 days later cell suspensions derived from the dopamine-rich ventral mesencephalic area were injected into the right rostral striatum. The transplants rapidly developed a substantial innervation of one striatum, so that by 15 days after transplantation (21 days of age) animals rotated away from the reinnervated side in response to amphetamine. The amount of turning correlated with the extent of innervation of the striatum as determined by tyrosine hydroxylase immunocytochemistry. By 25 days post-transplantation (31 days of age), animals turned in response to stress as well as amphetamine, although this later-developing phenomenon was not associated with any significant change in the extent of dopamine innervation. A second group of animals was bilaterally dopamine-depleted at 3 days of age, but transplantation with nigral cell suspensions was delayed until maturity. Partial reinnervation of the rostral striatum occurred with this delayed transplant paradigm, and turning to both amphetamine and stress commenced at 15 days post-transplantation. In contrast to animals receiving transplants shortly after lesioning, these animals began to turn spontaneo...Continue Reading

References

Nov 15, 1988·The Journal of Comparative Neurology·R K CarderR D Lund
Nov 1, 1985·Annals of Neurology·A M SnyderM J Zigmond
Jan 1, 1985·Experimental Brain Research·J P HermanM Le Moal
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Feb 1, 1984·Behavioral Neuroscience·J P BrunoE M Stricker
Jan 18, 1980·Science·S M AntelmanD Kocan

❮ Previous
Next ❯

Citations

Jan 1, 1996·Neuroscience and Biobehavioral Reviews·J N JoyceB S Neal-Beliveau
Nov 1, 1995·Neurobiology of Aging·J L Mendoza-RamírezR Drucker-Colín
Sep 1, 1994·Progress in Neurobiology·J P Herman, N D Abrous
Apr 2, 2003·Brain Research. Brain Research Reviews·Eugen DavidsRoss J Baldessarini
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Jan 1, 1991·Annals of the New York Academy of Sciences·A M Snyder-Keller
Jan 5, 2007·Journal of Neuroscience Research·Stefan Jean-Pierre HaasOliver Schmitt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.