Development of drug intermediates by using direct organocatalytic multi-component reactions

Organic & Biomolecular Chemistry
Dhevalapally B RamacharyG Babul Reddy

Abstract

Novel, economic and environmentally friendly one-pot three-component Knoevenagel/hydrogenation (K/H) and four-component Knoevenagel/hydrogenation/alkylation (K/H/A) reactions of ketones, CH-acids, dihydropyridines and alkyl halides using proline and proline/metal carbonate catalysis, respectively, have been developed. Many of the products of these K/H and K/H/A reactions have direct applications in pharmaceutical chemistry.

References

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Citations

Apr 14, 2015·Organic & Biomolecular Chemistry·Adluri B Shashank, Dhevalapally B Ramachary
Aug 8, 2017·Angewandte Chemie·Dhevalapally B RamacharyGuguloth Thirupathi
Feb 3, 2007·Organic & Biomolecular Chemistry·Dhevalapally B Ramachary, G Babul Reddy
Oct 19, 2007·Organic & Biomolecular Chemistry·Stephen J Connon
Oct 31, 2008·Organic & Biomolecular Chemistry·Dhevalapally B RamacharyMamillapalli Kishor
Mar 25, 2009·Chemistry : a European Journal·Dhevalapally B Ramachary, Rajasekar Sakthidevi
Aug 14, 2009·Organic & Biomolecular Chemistry·Dhevalapally B RamacharyKinthada Ramakumar
Jun 18, 2014·Organic & Biomolecular Chemistry·Dhevalapally B RamacharyY Vijayendar Reddy
Sep 16, 2016·ChemistrySelect·George N Pairas, Petros G Tsoungas
Jan 13, 2010·Organic & Biomolecular Chemistry·Dhevalapally B RamacharyChintalapudi Venkaiah
Dec 13, 2007·Chemical Reviews·Anniina ErkkiläPetri M Pihko
Feb 2, 2022·Organic & Biomolecular Chemistry·Tianxiang ZhuBinlin Zhao

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