Development of drug resistance in the population of colon cancer cells under the effect of multifunctional protein YB-1

Bulletin of Experimental Biology and Medicine
A V VaimanA A Stavrovskaya

Abstract

The effects of YB-1 gene on the expression level of P-glycoprotein and drug resistance of tumor cells were studied in cultured HCT116 colon cancer cells. Transitory transfection of chimeric YB-1/GFP gene rendered HCT116 cells a selective advantage in a medium with vinblastine, which caused translocation of the chimeric protein into cell nuclei. This was paralleled by an increase in the expression of P-glycoprotein (multiple drug resistance protein).

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Citations

Jul 9, 2008·Biochemistry. Biokhimii︠a︡·A A Stavrovskaya, T P Stromskaya
Feb 22, 2012·Biochemistry. Biokhimii︠a︡·I A EliseevaD N Lyabin
Mar 28, 2009·BMC Neuroscience·Bernadette UnkrüerHeidrun Potschka
Jan 4, 2013·PloS One·Dmitry N LyabinLev P Ovchinnikov
Dec 5, 2017·Experimental and Therapeutic Medicine·Hongyan LvJinqiao Zhang
Feb 9, 2017·Archives of Toxicology·Thomas Efferth, Manfred Volm

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