PMID: 11897927Mar 19, 2002Paper

Development of drugs that alter ventricular repolarization

American Journal of Therapeutics
Robert R Fenichel

Abstract

Many drugs are found to alter ventricular repolarization, as manifest by T-wave and U-wave changes on the surface electrocardiogram. These changes have frequently been associated with malignant ventricular arrhythmias. There is no perfectly sensitive and specific way of anticipating such arrhythmias, but some clinical and preclinical screening methods are better than others. The author reviews some of these methods, commenting on some of the regulatory implications.

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Citations

Jan 11, 2001·Journal of Pharmacological and Toxicological Methods·M R Gralinski
Feb 19, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Norman StockbridgeChristine Garnett
Apr 29, 2003·Journal of Cardiovascular Electrophysiology·Luc M HondeghemFred De Clerck
May 27, 2020·Journal of Cardiovascular Pharmacology·Vincenzo RussoGerardo Nigro

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