Development of dynorphin-like immunoreactive auditory nerve terminals in the chick

Brain Research. Developmental Brain Research
R A Code, A E McDaniel

Abstract

The novel discovery that auditory nerve terminals in the chick cochlear nucleus magnocellularis (NM) are immunoreactive for the opioid peptide dynorphin (DYN) was recently reported [3]. The present study examines the development of DYN-immunoreactivity (DYN-I) in auditory nerve terminals in NM from embryos through young post-hatch chicks. No DYN-I was observed in NM at embryonic day 13 (E13). DYN-I first appeared at E16 as short flat structures partially surrounding NM cell bodies. Around post-hatch day 1 (P1), these structures had a more rounded, chalice-type of morphology reminiscent of the specialized auditory nerve terminals found in birds, the end-bulbs of Held. At P6, most NM neurons were circumscribed by a prominent DYN-I calyceal-type of ending. By P13, fewer NM cells were ringed by this DYN-I and by the third post-hatch week, there was very little DYN-I in NM. There were no obvious differences in the density of DYN-I terminals across either the rostrocaudal length or the mediolateral width of NM at any age examined. These results suggest that during a restricted time of development, end-bulbs of Held in the chick NM contain DYN.

References

Nov 22, 1990·The Journal of Comparative Neurology·R A CodeE W Rubel
Sep 22, 1989·The Journal of Comparative Neurology·C S von BartheldE W Rubel
Jun 15, 1989·Hearing Research·R A Code, E W Rubel
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Oct 15, 1994·The Journal of Comparative Neurology·E A LachicaE W Rubel

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Citations

Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Jun 8, 2002·Annual Review of Neuroscience·Edwin W Rubel, Bernd Fritzsch

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