Development of early-born γ-Aminobutyric acid hub neurons in mouse hippocampus from embryogenesis to adulthood

The Journal of Comparative Neurology
Vincent VilletteAgnès Baude

Abstract

Early-born γ-aminobutyric acid (GABA) neurons (EBGNs) are major components of the hippocampal circuit because at early postnatal stages they form a subpopulation of "hub cells" transiently supporting CA3 network synchronization (Picardo et al. [2011] Neuron 71:695-709). It is therefore essential to determine when these cells acquire the remarkable morphofunctional attributes supporting their network function and whether they develop into a specific subtype of interneuron into adulthood. Inducible genetic fate mapping conveniently allows for the labeling of EBGNs throughout their life. EBGNs were first analyzed during the perinatal week. We observed that EBGNs acquired mature characteristics at the time when the first synapse-driven synchronous activities appeared in the form of giant depolarizing potentials. The fate of EBGNs was next analyzed in the adult hippocampus by using anatomical characterization. Adult EBGNs included a significant proportion of cells projecting selectively to the septum; in turn, EBGNs were targeted by septal and entorhinal inputs. In addition, most EBGNs were strongly targeted by cholinergic and monoaminergic terminals, suggesting significant subcortical innervation. Finally, we found that some EBGNs ...Continue Reading

References

Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T F FreundK Tóth
Sep 1, 1989·The Journal of Physiology·Y Ben-AriJ L Gaiarsa
Jan 30, 1989·Brain Research·T F Freund
Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Jul 1, 1983·Physiological Reviews·S L FooteG Aston-Jones
Jan 23, 1995·The Journal of Comparative Neurology·R LinkeM Frotscher
Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Dec 1, 1996·Cell and Tissue Research·T DellerM Frotscher
May 4, 2001·Brain Research. Developmental Brain Research·J L GaïarsaY Ben-Ari
Nov 21, 2001·Nature Reviews. Neuroscience·O Marín, J L Rubenstein
Dec 23, 2003·The European Journal of Neuroscience·Anastasia LudwigClaudio Rivera
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zsolt BorhegyiTamás F Freund
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesco FerragutiYannis Dalezios
Jan 26, 2006·Hippocampus·Rosa CossartChristophe Bernard
Aug 3, 2006·Nature Reviews. Neuroscience·Carl P Wonders, Stewart A Anderson
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shozo JinnoPeter Somogyi
Oct 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew FogartyNicoletta Kessaris
Dec 25, 2007·Developmental Biology·Carl P WondersStewart A Anderson
Feb 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Veronika Zsiros, Gianmaria Maccaferri
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Renata Batista-BritoGord Fishell
Jun 12, 2008·The Journal of Comparative Neurology·David J CoxFiona E N LeBeau
Jun 24, 2008·Nature Reviews. Neuroscience·UNKNOWN Petilla Interneuron Nomenclature GroupRafael Yuste
Jul 30, 2008·The European Journal of Neuroscience·Virág T TakácsAttila I Gulyás
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pablo FuentealbaPeter Somogyi
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Camille AllèneRosa Cossart
Nov 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel DoischerMarlene Bartos
Feb 20, 2009·The Journal of Comparative Neurology·Tyler Fortune, Diana I Lurie
Apr 14, 2009·Cerebral Cortex·Vitor H SousaGord Fishell
May 5, 2009·Neuron·Aaron G BlankenshipMarla B Feller
May 12, 2009·Current Topics in Developmental Biology·Renata Batista-Brito, Gord Fishell
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin W OkatySacha B Nelson
Jun 26, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Balázs HangyaViktor Varga
Oct 17, 2009·Science·Viktor VargaTamás F Freund
Dec 3, 2009·Nature Reviews. Neuroscience·Aaron G Blankenship, Marla B Feller

❮ Previous
Next ❯

Citations

Sep 29, 2017·Physiological Reviews·Kenneth A PelkeyChris J McBain
Aug 5, 2017·Frontiers in Cellular Neuroscience·William C Spencer, Evan S Deneris
Oct 12, 2017·Frontiers in Neuroanatomy·Audrey Mercer, Alex M Thomson
Oct 15, 2019·ELife·Zoé Christenson WickEsther Krook-Magnuson
Sep 13, 2020·Nature Communications·Marco BocchioRosa Cossart
Jul 20, 2021·Physiological Reviews·Rosa Cossart, Roustem Khazipov

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
electron microscopy

Key Resources (RRID) Mentioned

nif

Software Mentioned

Axoscope
Clampfit
Neurolucida
Matlab
MiniAnalysis

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.