PMID: 8612320Nov 21, 1995Paper

Development of endothelial nitric oxide synthase in endothelial cells in the human cerebrum

Brain Research. Developmental Brain Research
T MiyawakiS Takashima

Abstract

We demonstrate the distribution and development of endothelial nitric oxide synthase (eNOS) immunoreactivity in vessels of the human brain. eNOS-positive endothelial cells were recognized in small vessels in the parenchyma of the cerebrum, as well as in the large arteries and veins in the leptomeninges. By 10-13 weeks of gestation, eNOS-positive endothelial cells had already appeared in the vessels of the leptomeninges and deep white matter. Immunoreactivity for eNOS was noted in most vessels at 14-17 weeks in the intermediate white matter, at 18-21 weeks in the cortex, and at 23-26 weeks in the subcortical white matter. Such differences in regional development may be responsible in part for the topographical predilection for hemorrhagic or hypoxic-ischemic lesions in the developing brain.

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Citations

Jun 25, 1998·American Journal of Respiratory Cell and Molecular Biology·Q El DwairiS N Hussain
May 9, 2014·Journal of Pineal Research·Emilio A HerreraAníbal J Llanos
Jan 19, 2006·Journal of Child Neurology·Rebecca D Folkerth
Jan 15, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T C BeasleyD Busija
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Jan 1, 1997·The British Journal of Dermatology·A RoweC B Bunker

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