Development of endothelin receptors in perinatal rabbit pulmonary resistance arteries

British Journal of Pharmacology
C Docherty, M R MacLean

Abstract

1. Contractile responses to endothelin-1 (ET-1) and sarafotoxin S6c (S6c) were studied in pulmonary resistance arteries (approximately 320 microm i.d.) from fetal, 0-24 h, 4 day and 7 day rabbits. The effects of the ET(A)-selective antagonist FR139317, the selective ET(B) receptor antagonist BQ-788 and the non-selective ET(A)/ ET(B) receptor antagonist SB 209670, on these responses, were determined. Acetylcholine-induced vasodilation and noradrenaline-evoked contractions were also examined. 2. ET-1 potency was in the following order (pEC50 values): fetal (8.7) = 0-24 h (8.8) = 4 day (8.6) > 7 day (8.0). The order of potency for S6c was 7 days (11.1) = 4 days (10.8) > 0-24 h (9.7) > fetal (8.6). Hence, S6c and ET-1 were equipotent in the fetus but S6c was increasingly more potent than ET-1 with increasing age, being some 1000 times more potent by 7 days. By 7 days, responses to ET-1 were also resistant to both FR139317 and BQ-788. FR139317 inhibited responses to ET-1 in vessels from 0-24 h and 4 day, but not fetal, rabbits (pKb: 6.4 in 4 day rabbits). BQ-788 inhibited responses to ET-1 at all age points except for 7 days (pKb: 6.7 at 0-24 h; 6.2 at 4 days). BQ-788 inhibited responses to S6c at all age points (pKb: 8.5 at 4 days)...Continue Reading

References

Jun 1, 1992·British Journal of Pharmacology·S F LiuP J Barnes
Nov 1, 1992·British Journal of Pharmacology·M J SumnerI S Watts
Mar 25, 1991·Biochemical and Biophysical Research Communications·D L WilliamsB V Clineschmidt
Mar 15, 1991·Annals of Internal Medicine·D J StewartD Langleben
Jun 1, 1989·Trends in Pharmacological Sciences·Y Kloog, M Sokolovsky
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A InoueT Masaki
Oct 1, 1985·Chest·N C Staub
Apr 1, 1984·Biochemical Pharmacology·A BobikP J Little
Jun 1, 1984·American Journal of Diseases of Children·J R HagemanT H Gardner
May 1, 1994·Journal of Cardiovascular Pharmacology·M R MacLeanM Baird
Jul 1, 1995·Archives of Disease in Childhood. Fetal and Neonatal Edition·A A HislopS G Haworth
May 1, 1995·American Journal of Respiratory Cell and Molecular Biology·A A HislopS G Haworth
Jan 1, 1993·Developmental Pharmacology and Therapeutics·A Malamitsi-PuchnerD Nicolopoulos
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·E H OhlsteinJ S Frazee
May 1, 1994·Journal of Applied Physiology·T FukurodaM Nishikibe
Jun 1, 1994·British Journal of Pharmacology·S MorelandA Seymour
May 23, 1994·European Journal of Pharmacology·D G WhiteI S Watts
Mar 30, 1994·Biochemical and Biophysical Research Communications·T FukurodaM Nishikibe
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·K IshikawaT Nagase
Oct 15, 1993·Biochemical and Biophysical Research Communications·D M LaDouceurS J Haleen
Sep 1, 1995·Experimental Physiology·S G Haworth
Oct 11, 1996·The Journal of Biological Chemistry·N A ElshourbagyP Nambi
Jul 1, 1996·British Journal of Pharmacology·D W HayE H Ohlstein
Jan 1, 1996·Biology of the Neonate·A EndoK Sato
Nov 1, 1996·British Journal of Pharmacology·K M McCullochM R MacLean
Aug 1, 1996·Canadian Journal of Physiology and Pharmacology·A M Sharifi, E L Schiffrin
May 22, 1998·Journal of Cardiovascular Pharmacology·M R MacLeanC C Docherty

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Citations

Jan 30, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Margrid B SchindlerSheila G Haworth
Oct 21, 2010·Physiological Reviews·Yuansheng Gao, J Usha Raj
Feb 24, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C C DochertyP W Nathanielsz
Feb 8, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eduardo VillamorCarlos E Blanco

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