Development of enteric-coated calcium pectinate microspheres intended for colonic drug delivery

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Francesca MaestrelliP Mura

Abstract

Enteric-coated calcium pectinate microspheres (MS) aimed for colon drug delivery have been developed, by using theophylline as a model drug. The influence of pectin type (amidated or non-amidated) and MS preparation conditions (CaCl2 concentration and cross-linking time) was investigated upon the drug entrapment efficiency and its release behaviour. Drug stability and drug-polymer interactions were studied by Differential Scanning Calorimetry, thermogravimetry, X-ray diffractometry and FTIR spectroscopy. Enteric coating with Eudragit S100 enabled maintenance of MS integrity until its expected arrival to colon. The coating was also useful to improve the stability of MS during storage, avoiding morphologic changes observed for uncoated MS stored under ambient conditions. Entrapment efficiency increased by reducing cross-linking time, and (only in the case of non-amidated pectin) by increasing CaCl2 concentration. On the other hand, release tests performed simulating the gastro-intestinal pH variation evidenced an inverse relationship between CaCl2 concentration and drug release rate, whereas no influence of both pectin type and cross-linking time was found. Unexpectedly, addition of pectinolytic enzymes to the colonic medium did ...Continue Reading

References

Aug 1, 1990·Biopharmaceutics & Drug Disposition·A Rubinstein
Jan 1, 1994·Journal of Drug Targeting·M Ashford, J T Fell
Jun 1, 1997·The Journal of Pharmacy and Pharmacology·Z WakerlyD Parkins
Oct 31, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M RodríguezD Torres
Jul 27, 2001·International Journal of Pharmaceutics·V R Sinha, R Kumria
Mar 7, 2002·International Journal of Pharmaceutics·Libo YangJoseph A Fix
May 24, 2003·Biomaterials·LinShu LiuKevin B Hicks
Nov 7, 2003·International Journal of Pharmaceutics·Pornsak Sriamornsak, Nartaya Thirawong
Dec 12, 2003·Journal of Drug Targeting·Paola MuraAntonio M Rabasco Alvarez
Jun 17, 2004·AAPS PharmSciTech·Srisagul SungthongjeenSatit Puttipipatkhachorn
Nov 24, 2004·Advanced Drug Delivery Reviews·David R Friend
Jun 23, 2006·International Journal of Pharmaceutics·O ChambinY Pourcelot
Jul 11, 2006·International Journal of Pharmaceutics·Sandrine BourgeoisElias Fattal

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Citations

Mar 1, 2012·Applied Biochemistry and Biotechnology·Luciana CostasGuillermo R Castro
Jan 5, 2011·AAPS PharmSciTech·Tin Wui WongFabio Sonvico
Jan 13, 2011·AAPS PharmSciTech·Priya BawaPradeep Kumar
Aug 10, 2011·Journal of Microencapsulation·Lin ZhangGuangxi Zhai
Jan 15, 2016·Journal of Drug Targeting·Lin ZhangAili Zhao
Sep 4, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lorena SegaleFranco Pattarino
May 24, 2011·International Journal of Pharmaceutics·Claire DhalleineOdile Chambin
May 5, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Glen PereraAndreas Bernkop-Schnürch
Oct 17, 2009·International Journal of Pharmaceutics·Surajit Das, Ka-Yun Ng
Sep 30, 2008·International Journal of Pharmaceutics·H P de OliveiraJ Rieumont
Mar 25, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·F MaestrelliP Mura
Aug 16, 2015·International Journal of Pharmaceutics·Pseidy Luz MamaniMaría Dolores Veiga
May 4, 2011·Molecular Nutrition & Food Research·Anett OehmePeter Schreier
Sep 27, 2014·Carbohydrate Polymers·Fabíola Garavello PrezottiRaul Cesar Evangelista
Apr 2, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sachin Kumar SinghYogyata Vaidya
Jan 21, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Niranjan Goud KotlaAshwini Shivapooja
Mar 10, 2017·Journal of Drug Targeting·M Junaid DarGul Majid Khan
Jun 26, 2009·Pharmaceutical Development and Technology·Vinayak D Kadam, Surendra G Gattani
Nov 4, 2009·Pharmaceutical Development and Technology·Zaheeda KhanLisa C du Toit
Feb 27, 2015·Materials·M Biswaranjan SubudhiSanjay K Jain
Apr 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Claudia Lara-EspinozaAgustín Rascón-Chu
Jan 26, 2020·International Journal of Pharmaceutics·Hytham H GadallaGhareb M Soliman
Jun 21, 2021·International Journal of Pharmaceutics·Surajit Das
Jun 12, 2014·Journal of Agricultural and Food Chemistry·Xiujun GuoXuesong Huang
Oct 25, 2017·Molecular Pharmaceutics·Marta González-AlvarezFélix Sancenón

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