PMID: 9650454Jul 3, 1998Paper

Development of Epstein-Barr virus-associated B cell lymphoma after intensive treatment of patients with angioimmunoblastic lymphadenopathy with dysproteinemia

International Journal of Hematology
K MatsueY Hirose

Abstract

Evolution of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) into aggressive B cell lymphoma is thought to be a rare event and the cause of this transformation has not been fully elucidated. We describe two patients with AILD that progressed to aggressive large-cell lymphoma with a B cell phenotype. At presentation, the lymph nodes of both patients showed the typical features of AILD by hematoxylin-eosin staining. Immunohistochemical staining with monoclonal antibodies revealed positive staining of atypical cells with UCHL-1 and negative staining with L-26. In situ hybridization of EBV RNA showed rare positive cells in one patient and was negative in the other patient. At relapse, both patients showed systemic lymph nodes swelling, which is characteristic of diffuse large immunoblastic lymphoma. Single-cell analysis with monoclonal antibodies and immunohistochemical staining showed the monoclonal proliferation of B cells. Southern blot analysis of the lymph nodes showed a rearrangement in both patients of the Ig heavy chain gene and germ line configuration of the T cell receptor beta chain gene. Southern blot analysis using the EBV terminal repeat region probe detected clonal proliferation of EBV in the lymph node...Continue Reading

Citations

Feb 1, 2014·International Journal of Hematology·Pier Paolo PiccalugaStefano A Pileri
Aug 27, 2002·Advances in Anatomic Pathology·Judith A Ferry
Oct 3, 2002·Leukemia·C Lome-MaldonadoUNKNOWN French Groupe d'Etude des Lymphomes de l'Adulte (GELA)
Mar 25, 2017·The Journal of Pathology·Friederike H SchwartzRalf Küppers
Apr 25, 2001·Histopathology·H K Müller-HermelinkG Ott
Jun 27, 2007·The American Journal of Surgical Pathology·Nicolas OrtonnePhilippe Gaulard
Nov 2, 2006·Archives of Pathology & Laboratory Medicine·Robert C HawleyRichard J Zarbo

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