Development of estradiol-positive feedback on luteinizing hormone release in the female rat: a quantitative study

Endocrinology
W W AndrewsS R Ojeda

Abstract

Experiments were conducted to study, in a quantitative manner, the development of estradiol (E2)-positive feedback on LH release in the female rat. A Silastic capsule (20 mm in length/100 g BW) containing E2 dissolved in corn oil (400 micrograms/ml) reproduced first proestrous levels of serum E2 when implanted sc in juvenile rats of different ages (days 20-32). When similar capsules were implanted in infantile rats (days 10-18), serum E2, measured 2 days later, was found to be extremely elevated in 12- and 14-day-old rats (4-6 times higher than first proestrous levels), declining thereafter so that in 16- to 20-day-old rats the levels were only 2-fold greater than proestrous values. Serum levels of alpha-fetoprotein decreased markedly between days 12-28, and both normal and implant-produced serum E2 levels paralleled the decline in the protein titers. However, calculation of the total E2 binding capacity of alpha-fetoprotein indicated that in addition to binding to this protein, there are additional factors responsible for the persistence of E2 in the serum of infantile rats. A LH surge could not be induced in 12- or 14-day-old rats by a 48-h E2 pulse, despite the presence of substantial amounts of free E2, which exerted profou...Continue Reading

Citations

Oct 9, 2007·Psychopharmacology·Mahin ShahbaziKyle J Frantz
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·M A WeinsteinR J Barfield
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·J A MoguilevskyP Scacchi
Apr 17, 1999·European Journal of Pharmacology·K Frantz, C Van Hartesveldt
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·K J Frantz, C Van Hartesveldt
Aug 26, 1998·The Journal of Steroid Biochemistry and Molecular Biology·M E Wilson, R J Handa
Nov 22, 2008·Endocrinology·Valerie MatagneSergio R Ojeda
Apr 23, 2013·The Journal of Endocrinology·Hiroto KobayashiAkira Naito
Jan 29, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·J S RedmondM Amstalden
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z WeihuaJ A Gustafsson
Jan 30, 2010·Molecular and Cellular Endocrinology·Jenny ClarksonAllan E Herbison
Mar 3, 2004·Annals of the New York Academy of Sciences·Valérie MatagneJean-Pierre Bourguignon
Jul 18, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·David A Beckman, Maureen Feuston
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Kalynn M Schulz, Cheryl L Sisk
Apr 25, 2001·Biology of Reproduction·A C Whitney, A S Clark
Nov 18, 2019·Anatomical Science International·Hiroto Kobayashi

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