Development of excitatory circuitry in the hippocampus

Journal of Neurophysiology
A Y HsiaR A Nicoll

Abstract

Assessing the development of local circuitry in the hippocampus has relied primarily on anatomic studies. Here we take a physiological approach, to directly evaluate the means by which the mature state of connectivity between CA3 and CA1 hippocampal pyramidal cells is established. Using a technique of comparing miniature excitatory postsynaptic currents (mEPSCs) to EPSCs in response to spontaneously occurring action potentials in CA3 cells, we found that from neonatal to adult ages, functional synapses are created and serve to increase the degree of connectivity between CA3-CA1 cell pairs. Neither the probability of release nor mean quantal size was found to change significantly with age. However, the variability of quantal events decreases substantially as synapses mature. Thus in the hippocampus the developmental strategy for enhancing excitatory synaptic transmission does not appear to involve an increase in the efficacy at individual synapses, but rather an increase in the connectivity between cell pairs.

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Citations

Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A Y HsiaL Mucke
Apr 5, 2001·Journal of Neurophysiology·T C Foster, T C Dumas
Apr 23, 2002·Nature Neuroscience·J Julius Zhu, Roberto Malinow
Jun 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Daniel H O'ConnorSamuel S-H Wang
Jul 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·Majid H MohajeraniEnrico Cherubini
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julia VaglenovaClark Randal
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Jul 30, 2010·Journal of Neurophysiology·Jason Tait SanchezAndres Barria
Jul 5, 2013·The International Journal of Neuropsychopharmacology·Chao-Chuan WangPo See Chen
Nov 10, 2013·Nature Reviews. Neuroscience·Eric HanseIlse Riebe
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Feb 22, 2012·The Journal of Physiology·Elena E Bagley, Gary L Westbrook

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