Abstract
To develop different thrombus analogues, with mechanical properties similar to those of human fibrinous thrombus, for in-vitro aneurysm sac pressure studies. Using dynamic mechanical analysis we determined the E-modulus (/E(*)/) at 0.8, 1.0, 1.5 and 3.9 Hz of ten different human fibrinous thrombus samples. We also determined loss and storage modulus to quantify the visco-elastic properties. For comparison, we measured the E-modulus (|E(*)|), loss and storage modulus of gelatin, Novalyse ST8, ST14 and ST20 with and without contrast agent. Mean E-modulus of the thrombus samples (SD) at 0.8, 1.0, 1.5 and 3.9 Hz was 39 (16), 37 (15), 37 (15) and 38 (14)kPa, respectively. Median (SD) storage and loss modulus were 35 (12) and 8 (4)kPa, respectively. Median (SD) tandelta was 0.25 (0.06). The E-modulus of gelatin, Novalyse ST8, ST14 and ST20 was 4, 27, 48 and 60 kPa, respectively. The E-modulus of Novalyse ST8, ST14 and ST20 mixed with contrast agent was 18, 23 and 33 kPa, respectively. Median (SD) storage, loss modulus and tan delta of the six Novalyse samples were 30 (15), 3 (1) and 0.087 (0.04), respectively. All the thrombus analogues, except gelatin, had an E-modulus in the range of human fibrinous thrombi. Novalyse samples are va...Continue Reading
References
Nov 1, 1991·Annals of Vascular Surgery·J C ParodiH D Barone
Sep 1, 1993·The American Review of Respiratory Disease·S Q Liu, Y C Fung
Feb 1, 1996·Journal of Endovascular Surgery : the Official Journal of the International Society for Endovascular Surgery·G H WhiteJ May
May 12, 1998·Journal of Vascular Surgery·D A VorpM W Webster
Jun 4, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E Di MartinoR Fumero
Jan 11, 2002·Journal of Biomechanical Engineering·D H WangD A Vorp
Aug 23, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·A W Floris VosJan A Rauwerda
Aug 23, 2003·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Srinivasa R VallabhaneniPeter L Harris
Feb 5, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A ChaudhuriM Adiseshiah
Sep 8, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A ChaudhuriM Adiseshiah
Sep 8, 2004·Lancet·R M GreenhalghUNKNOWN EVAR trial participants
Nov 9, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·B LindbladB Sonesson
May 6, 2005·Journal of Vascular Surgery·Carlos H TimaranJohn P Pacanowski
Aug 27, 2005·Journal of Biomechanical Engineering·Z Li, C Kleinstreuer
Dec 27, 2005·Journal of Vascular Surgery·Jan-Willem HinnenHajo J Van Bockel
Citations
Jun 9, 2010·Journal of Biomechanical Engineering·T J CorbettT M McGloughlin
Aug 25, 2006·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Arindam Chaudhuri
May 12, 2007·Biomechanics and Modeling in Mechanobiology·Evelyne A van DamFrans N van de Vosse
Apr 24, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Constance L SlabochTimothy C Ovaert
Apr 12, 2011·Medical Engineering & Physics·Florentina EneLiam Morris
Dec 9, 2008·Journal of Biomechanics·John H AshtonDarren G Haskett
Feb 26, 2014·Journal of Biomechanics·Siobhan A O'LearyBarry J Doyle
Dec 1, 2009·Journal of Vascular Surgery·Lambert SpeelmanMichael H Jacobs
May 22, 2016·Ultrasound in Medicine & Biology·John J BlackJohn J Pacella
Oct 25, 2016·Medical Engineering & Physics·Florian StefanovLiam Morris
Jun 5, 2012·Vascular·W M P F BosmanJ F Hamming
Aug 30, 2008·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Timothy J CorbettTim M McGloughlin
May 20, 2015·Annals of Biomedical Engineering·Jianhua Tong, Gerhard A Holzapfel
Apr 27, 2017·Vascular·Kim van NoortJean-Paul Pm de Vries
Jul 22, 2020·Annals of Biomedical Engineering·Sarah JohnsonJ Patrick McGarry
Aug 30, 2017·Annals of Biomedical Engineering·S JohnsonP E McHugh
Mar 5, 2010·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Timothy J CorbettTim M McGloughlin
Jul 26, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Matthew J MooreBarry J Doyle