Development of fibrinous thrombus analogue for in-vitro abdominal aortic aneurysm studies

Journal of Biomechanics
J W HinnenJ F Hamming

Abstract

To develop different thrombus analogues, with mechanical properties similar to those of human fibrinous thrombus, for in-vitro aneurysm sac pressure studies. Using dynamic mechanical analysis we determined the E-modulus (/E(*)/) at 0.8, 1.0, 1.5 and 3.9 Hz of ten different human fibrinous thrombus samples. We also determined loss and storage modulus to quantify the visco-elastic properties. For comparison, we measured the E-modulus (|E(*)|), loss and storage modulus of gelatin, Novalyse ST8, ST14 and ST20 with and without contrast agent. Mean E-modulus of the thrombus samples (SD) at 0.8, 1.0, 1.5 and 3.9 Hz was 39 (16), 37 (15), 37 (15) and 38 (14)kPa, respectively. Median (SD) storage and loss modulus were 35 (12) and 8 (4)kPa, respectively. Median (SD) tandelta was 0.25 (0.06). The E-modulus of gelatin, Novalyse ST8, ST14 and ST20 was 4, 27, 48 and 60 kPa, respectively. The E-modulus of Novalyse ST8, ST14 and ST20 mixed with contrast agent was 18, 23 and 33 kPa, respectively. Median (SD) storage, loss modulus and tan delta of the six Novalyse samples were 30 (15), 3 (1) and 0.087 (0.04), respectively. All the thrombus analogues, except gelatin, had an E-modulus in the range of human fibrinous thrombi. Novalyse samples are va...Continue Reading

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Citations

Aug 25, 2006·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Arindam Chaudhuri
May 12, 2007·Biomechanics and Modeling in Mechanobiology·Evelyne A van DamFrans N van de Vosse
Apr 24, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Constance L SlabochTimothy C Ovaert
Apr 12, 2011·Medical Engineering & Physics·Florentina EneLiam Morris
Dec 1, 2009·Journal of Vascular Surgery·Lambert SpeelmanMichael H Jacobs
Aug 30, 2008·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Timothy J CorbettTim M McGloughlin
May 20, 2015·Annals of Biomedical Engineering·Jianhua Tong, Gerhard A Holzapfel
Jul 22, 2020·Annals of Biomedical Engineering·Sarah JohnsonJ Patrick McGarry
Mar 5, 2010·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Timothy J CorbettTim M McGloughlin
Jul 26, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Matthew J MooreBarry J Doyle

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