PMID: 8971879Dec 1, 1996Paper

Development of focal segmental sclerosis and hyalinosis in hemolytic uremic syndrome

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M G CalettiC A Gianantonio

Abstract

Renal biopsies from 19 boys and 11 girls, most with moderate or severe forms of hemolytic uremic syndrome (HUS) of the classic diarrhea-associated type, were analyzed as part of their long-term follow-up. Patients were biopsied because of late or persistent proteinuria, hypertension, and prolonged renal failure. The median length of follow-up was 11.2 years (range 0.9-22.0 years). Four histological groups were identified: focal segmental glomerulosclerosis and hyalinosis (FSGSH) (17 patients), diffuse mesangial proliferative glomerulonephritis (DMPGN) (9 patients), diffuse glomerulosclerosis (2 patients), and minimal glomerular changes (2 patients). The median interval between the onset of disease and renal biopsy was significantly shorter in DMPGN than in FSGSH (P < 0.001). The pathological findings may be the expression of two different stages of the same dynamic process: a regular sequence of glomerular lesions consisting of early DMPGN, followed by FSGSH. This lesion would ultimately lead to the final stage of global glomerulosclerosis. At the last examination, only a quarter of the patients had normal renal function. These observations also confirm that prolonged oligoanuria during the acute stage of HUS frequently results...Continue Reading

Citations

May 10, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Robert S OakesRichard L Siegler
Feb 17, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·María Gracia CalettiAdriana Haydeé Roy
May 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maria Gracia CalettiStella Maris Rasse
Apr 6, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alejandro BalestracciRaquel Eva Wainsztein
Dec 20, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·María Gracia CalettiClarisa Vezzani
Jan 5, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joann M SpinaleBernard S Kaplan
Feb 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alejandro BalestracciRaquel Eva Wainsztein
Oct 10, 1998·Kidney International·M SimonH E Abboud
Jun 9, 2000·Kidney International·K E Meyers, B S Kaplan
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Jan 4, 1998·Kidney International·H A Repetto
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Apr 20, 2014·The Journal of Pediatrics·Sharon P Andreoli
Dec 16, 2016·Journal of the American Society of Nephrology : JASN·Rachel C ChallisDavid Kavanagh
Mar 16, 2017·Ultrastructural Pathology·Wiesława Salwa-ŻurawskaPiotr Tabaczewski
Dec 6, 2017·The Journal of Pathology·Alfonso Rubio-NavarroJuan Antonio Moreno
Nov 24, 2019·Pediatrics International : Official Journal of the Japan Pediatric Society·Alejandro BalestracciMaría Gracia Caletti
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