Development of functional protein microarrays for drug discovery: progress and challenges

Combinatorial Chemistry & High Throughput Screening
Fang X ZhouPaul F Predki

Abstract

Functional protein microarrays promise new approaches to address longstanding challenges in drug discovery and development, with applications ranging from target identification to clinical trial design. However, their widespread adoption will be contingent upon a robust ability to develop and manufacture arrays in support of these applications. This review will address the major areas of relevance to the development of functional protein microarrays; protein content, surface chemistry, manufacture and assay development. Successful development will empower multiple drug research applications, help fill future HTS pipelines and guide next generation combinatorial chemistry efforts.

Citations

Jul 19, 2008·Annual Review of Analytical Chemistry·David A Egas, Mary J Wirth
Jul 13, 2005·Molecular & Cellular Proteomics : MCP·Tanja FeilnerBirgit Kersten
Feb 16, 2005·Anti-cancer Drugs·Valeria Gonzalez-Nicolini, Martin Fussenegger
Jun 15, 2006·Chemical Reviews·Daniel P Walsh, Young-Tae Chang

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