Development of gastroretentive drug delivery system for cefuroxime axetil: in vitro and in vivo evaluation in human volunteers

Pharmaceutical Development and Technology
Ramesh Bomma, Kishan Veerabrahma

Abstract

The objective of this investigation was to develop the cefuroxime axetil sustained-release floating tablets to prolong the gastric residence time and compare their pharmacokinetic behavior with marketed conventional tablets (Zocef). The floating tablets were developed using polymers like HPMC K4M and HPMC K100M alone, and polymer combination of HPMC K4M and Polyox WSR 303 by effervescent technique. Tablets were prepared by slugging method and evaluated for their physical characteristics, in vitro drug release, and buoyancy lag time. The best formulation (F10) was selected based on in vitro characteristics and used in vivo radiographic and bioavailability studies in healthy human volunteers. All the formulations could sustain drug release for 12 h. The dissolution profiles were subjected to various kinetic release models and it was found that the mechanism of drug release followed Peppas model. The in vivo radiographic studies revealed that the tablets remained in stomach for 225 ± 30 min. Based on in vivo performance, the developed floating tablets showed superior bioavailability than Zocef tablet. Based on in vivo performance significant difference was observed between Cmax, tmax, t1/2, AUC0-∞, and mean residence time of test ...Continue Reading

References

Oct 1, 1984·British Journal of Clinical Pharmacology·D K SommersH S Schoeman
Dec 22, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·B N Singh, K H Kim
Feb 17, 2000·International Journal of Pharmaceutics·S BaumgartnerB Zorko
Mar 11, 2000·Critical Reviews in Therapeutic Drug Carrier Systems·A Hoffman, D Stepensky
Jun 6, 2000·Advanced Drug Delivery Reviews·A Hoffman
Aug 1, 2000·International Journal of Pharmaceutics·P Ruiz-CarreteroV G Casabo
May 23, 2001·Advanced Drug Delivery Reviews·J Siepmann, N A Peppas
Feb 3, 2007·Current Drug Delivery·M JaiminiY S Tanwar
Jul 1, 2009·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Ramesh BommaKishan Veerabrahma
Feb 2, 2012·PDA Journal of Pharmaceutical Science and Technology·Mohan GugulothKishan Veerabrahma

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Citations

Oct 26, 2021·Medicinal Research Reviews·Malihe PooresmaeilAhmad Shaabani

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