Development of genipin-crosslinked fucoidan/chitosan-N-arginine nanogels for preventing Helicobacter infection

Nanomedicine
Yu-Hsin LinFwu-Long Mi

Abstract

This study aims to validate the anti-Helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection. Genipin-crosslinked low molecular weight fucoidan/chitosan-N-arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells. The negatively charged nanogels (n-FCSA) adhered to H. pylori and exhibited pH-responsive drug release property to reduce cytotoxic effects in H. pylori infected AGS cells. These in vitro findings suggest that n-FCSA nanogels are potential carriers for H. pylori specific delivery of antibacterial agents, and provide the basis for further studies on the clinical use of the nanogels.

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Citations

Oct 12, 2019·Marine Drugs·Helen J FittonSamuel N Karpiniec
Dec 14, 2018·Current Medicinal Chemistry·Cláudia Nunes, Manuel A Coimbra
May 13, 2020·Food & Function·Carla Palacios-GorbaMaria Consuelo Pina-Pérez
Feb 5, 2021·International Journal of Pharmaceutics·Fernanda C MoraesDidier Letourneur
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Chih-Wei ChiangEr-Yuan Chuang
Nov 13, 2020·Biotechnology Advances·Amaia Huguet-CasqueroJose Luis Pedraz
Jun 17, 2021·Critical Reviews in Food Science and Nutrition·Xiaomin ZhangChanghu Xue
Sep 11, 2020·Biomacromolecules·Alina Gabriela RusuLiliana Mititelu-Tartau
Sep 28, 2021·Critical Reviews in Microbiology·Cláudia SousaLuís D R Melo

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Methods Mentioned

BETA
transfection
dynamic light scattering
transmission electron microscopy
Fluorescence

Software Mentioned

LCS Lite

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