PMID: 6981023May 1, 1982Paper

Development of glomerular lesions in experimental long-term diabetes in the rat

Kidney International
K HiroseH J Gundersen

Abstract

Exact parameters for relevant glomerular structures in the course of streptozotocin diabetes in rats with 1 to 18 months' duration were obtained with stereological methods. Renal cortical tissue from diabetic (D) and control animals (C) was processed for light- and electron microscopy and measurements were performed on systematically sampled glomeruli. The thickness of the basement membrane (BM) increased with age in both groups, but the rate of increase was 50% higher in D: 19 +/- 1.2 nm/month (mean +/- SD) vs. 13 +/- 0.9 nm/month, P = 0.0003. The time course of other structural quantities was characterized by the acute changes constituting the glomerular hypertrophy, earlier shown to develop within the first few days of diabetes. All these changes were confirmed in the present study: In the earliest phase the diabetic rats showed an increased total volume of glomeruli, mesangium, and mesangial BM material, as well as an increased surface of the capillary walls. However, none of these differences between the groups showed progression with increasing duration. Mesangial changes corresponding to those of the glomerulopathy in long-term diabetes were not demonstrable within the experimental period. The streptozotocin diabetic rat...Continue Reading

References

Jan 1, 1979·Journal of Microscopy·E B JensenR Osterby

❮ Previous
Next ❯

Citations

Mar 1, 1991·Diabetes/metabolism Reviews·G PuglieseJ R Williamson
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·N MarcussenS Christensen
Feb 1, 1990·Pflügers Archiv : European journal of physiology·M ElgerW Kriz
Jun 9, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Carla CarasiMichael J Dillon
Oct 1, 1995·Journal of Diabetes and Its Complications·D VranesM E Cooper
Jul 20, 2002·Journal of Diabetes and Its Complications·Alex M BirrellDennis K Yue
Dec 15, 2000·Kidney International·K J McCarthyJ H Johnson
Jan 12, 2002·Kidney International·David A MaddoxEdward T Zawada
Aug 8, 2002·Kidney International·Ian J RamageT James Beattie
Apr 13, 1989·The New England Journal of Medicine·B M ChaversS M Mauer
Jun 6, 2009·Molecular & Cellular Proteomics : MCP·Daniela M SchlatzerMark R Chance
Jun 1, 1990·Journal of Clinical Pathology·F E DischeV Parsons
Sep 14, 2006·American Journal of Physiology. Renal Physiology·Anil K BidaniKaren A Griffin
May 1, 1984·The Journal of Clinical Investigation·L D DworkinB M Brenner
Oct 1, 1984·The Journal of Clinical Investigation·S M MauerF C Goetz
Apr 1, 1989·The Journal of Clinical Investigation·J W Scholey, T W Meyer
Sep 1, 1989·The Journal of Clinical Investigation·A ChagnacB D Myers
Oct 1, 1990·The Journal of Clinical Investigation·K A Nath, A K Salahudeen
Sep 1, 1992·The Journal of Clinical Investigation·R A LafayetteT W Meyer
Jun 30, 2012·PloS One·Flavia G MachadoRoberto Zatz
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·J MegyesiR L Safirstein
Aug 26, 2014·Inflammopharmacology·Manpreet KaurPuneet Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.