Development of glucose intolerance and impaired plasma insulin response to glucose in obese hyperglycaemic (ob/ob) mice

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
P R Flatt, C J Bailey

Abstract

The development of glucose intolerance in Aston ob/ob mice showed a gross exaggeration of the age-related changes of glucose tolerance in lean (+/+) mice. Intraperitoneal glucose tolerance in ob/ob mice was poor at 5 weeks, improved by 10 weeks, but markedly worsened by 20 weeks. A 24 hour fast further exaggerated the glucose intolerance of ob/ob mice. Unlike lean mice, tolerance improved in ob/ob mice at 40 weeks. Alterations of insulin sensitivity and the plasma insulin response to glucose accounted in part for these observations. Insulin sensitivity deteriorated until 20 weeks, but improved at 40 weeks in both fed and 24 hour fasted ob/ob mice. A positive plasma insulin response to glucose was lost after 5 weeks in fed ob/ob mice. The severity of this abnormality corresponded with the extent of the basal hyperinsulinaemia. A 24 hour fast reduced plasma insulin concentrations and restored a positive plasma insulin response to glucose in ob/ob mice. The results suggest that the plasma insulin response to glucose in ob/ob mice is related to the secretory activity of the B-cells prior to stimulation. Furthermore, it is evident that factors in addition to insulin insensitivity and the impaired plasma insulin response to glucose c...Continue Reading

Citations

Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C J Bailey, P R Flatt
Dec 12, 2001·Molecular and Cellular Endocrinology·B H BreierW P Wong
Dec 18, 2003·The Journal of Clinical Investigation·Stefan KraussBradford B Lowell
Nov 1, 1993·Diabetes/metabolism Reviews·C J Bailey, P R Flatt
Jan 1, 1997·British Journal of Pharmacology·C J BaileyP R Flatt
Jan 24, 2016·Biochimica Et Biophysica Acta·Vadivel ParthsarathyVictor A Gault
Sep 1, 1985·Bioscience Reports·P R FlattC J Bailey
Mar 1, 1982·Metabolism: Clinical and Experimental·C J Bailey, P R Flatt
Jan 25, 2017·The Journal of Endocrinology·Srividya VasuPeter R Flatt
Oct 4, 2017·Human Molecular Genetics·Joon Hyun KwonJanice Y Chou
Aug 8, 2018·Endocrinology·Daniel FergusonCharles A Harris
Jan 1, 1988·Nutrition Research Reviews·L M MorganV Marks
Dec 25, 2009·Endocrinology·Steven T Russell, Michael J Tisdale
Mar 1, 1997·The Proceedings of the Nutrition Society·P R FlattF P O'Harte
Oct 1, 1995·The American Journal of Physiology·S G LaychockM S Patel

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