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Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Journal of Medicinal Chemistry

Mar 24, 2016

Vincent CrowleyBrian S J Blagg

Abstract

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and...read more

Mentioned in this Paper

Study
Antineoplastic Agents
Amides
Protein Digestion
Cell Motility
Cell Migration Inhibition Function
Structure-Activity Relationship
Analog
Amidate
HSP90AA1 gene
4
29
Paper Details
References
  • References52
  • Citations6
12345...
  • References52
  • Citations6
1

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Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold

Journal of Medicinal Chemistry

Mar 24, 2016

Vincent CrowleyBrian S J Blagg

PMID: 27003516

DOI: 10.1021/acs.jmedchem.6b00085

Abstract

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many proteins involved in cell adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and...read more

Mentioned in this Paper

Study
Antineoplastic Agents
Amides
Protein Digestion
Cell Motility
Cell Migration Inhibition Function
Structure-Activity Relationship
Analog
Amidate
HSP90AA1 gene
4
29

Similar Papers Found In These Feeds

Chaperones & Protein Folding

Chaperones are proteins that play an essential role in protein folding, stability, assembly, and degradation. Their depletion or dysfunction has been implicated in protein folding disorders. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Clinical Lymphoma, Myeloma & Leukemia

HSP90 inhibitors as therapy for multiple myeloma

Clinical Lymphoma, Myeloma & LeukemiaNovember 9, 2011
Saad Z Usmani, Gabriela Chiosis
Paper Details
References
  • References52
  • Citations6
12345...
  • References52
  • Citations6
1
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