Development of gold-core silica shell nanospheres coated with poly-2-ethyl-oxazoline and β-cyclodextrin aimed for cancer therapy

Materials Science & Engineering. C, Materials for Biological Applications
Catarina A ReisIlídio J Correia

Abstract

Cancer is one of the major world public health problems and the currently available treatments are nonspecific and ineffective. This reality highlights the importance of developing novel therapeutic approaches. In this field, multifunctional nanomedicines have the potential to revolutionize the currently available treatments. These unique nanodevices can simultaneously act as therapeutic and imaging agents allowing the real-time monitoring of the nanoparticles biodistribution and the treatment outcome. Among the different nanoparticles, the gold-core silica shell (AuMSS) nanoparticles advantageous physicochemical and biological properties make them promising nanoplatforms for cancer therapy. Nevertheless, their successful application as an effective cancer nanomedicine is limited by the unfavorable pharmacokinetics and uncontrolled release of the therapeutic payloads. Herein, a new polymeric coating for AuMSS nanospheres was developed by combining different ratios (25/75, 50/50 and 75/25) of two materials, Poly-2-ethyl-2-oxazoline (PEOZ) and β-cyclodextrin (β-CD). The surface functionalization of AuMSS nanospheres led to a size increase and to the neutralization of the surface charge. On the other side, the nanoparticles biolog...Continue Reading

Citations

May 2, 2020·Biomaterials Science·Natanael FernandesIlídio J Correia
Jul 1, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ziyuan LiZhongjun Du
Oct 4, 2020·IET Nanobiotechnology·Hasnat Tariq, Syed Ali Imran Bokhari
Sep 11, 2020·Acta Biomaterialia·Ariana S C GonçalvesIlídio J Correia
Nov 30, 2021·Biotechnology and Bioengineering·Ariana S C GonçalvesIlídio J Correia
Oct 9, 2021·Current Drug Delivery·Teng Meng Sheng, Palanirajan Vijayaraj Kumar

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