Development of heart failure in patients with rheumatoid arthritis: A Danish population-based study

European Journal of Clinical Investigation
Brian B LøgstrupMichael Maeng

Abstract

To investigate the incidence of heart failure (HF) and ischaemic heart disease (IHD) in different time spans following incident rheumatoid arthritis (RA) and, furthermore, to investigate the impact of IHD on the development of HF and the impact of different treatment era of RA. This matched cohort study used nationwide, prospectively collected data. From the total Danish population of approximately 5.7 million inhabitants, we identified 51 859 patients (between 1995 and July 2016) with incident RA and a sex- and age-matched cohort from the general population (256 653 persons). The hazard ratio (HR) for HF among RA patients compared with persons from comparison cohort was 2.28 within the first year of index date, 1.39 within the 1-5 years of index date and 1.38 within the 5-10 years of index date. No difference was identified regarding different treatment era of RA. For IHD, the subdistribution hazard ratio (sHR) was 1.93 within the first year of index date, 1.26 within the 1-5 years of index date and 1.31 within the 5-10 years of index date. Coronary revascularization was also more common within the first year after diagnosis of RA. An increased risk of percutaneous coronary intervention and coronary artery bypass grafting with...Continue Reading

References

Feb 27, 2004·The American Journal of Medicine·Frederick Wolfe, Kaleb Michaud
Feb 5, 2005·Arthritis and Rheumatism·Paulo J NicolaSherine E Gabriel
Mar 8, 2005·Arthritis and Rheumatism·Hilal Maradit-KremersSherine E Gabriel
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Oct 24, 2008·The American Journal of Medicine·Peter Libby
Jan 23, 2009·Lancet·Lars KlareskogStephen Paget
Jan 9, 2010·Annals of the Rheumatic Diseases·S E Gabriel
Mar 2, 2011·Arthritis and Rheumatism·Cynthia S CrowsonSherine E Gabriel
Mar 11, 2011·Annals of the Rheumatic Diseases·Jesper LindhardsenPeter Riis Hansen
May 17, 2011·The Journal of Rheumatology·Elena MyasoedovaSherine E Gabriel
Aug 4, 2011·Scandinavian Journal of Public Health·Carsten Bøcker Pedersen
Mar 1, 2012·Arthritis Research & Therapy·Jon T GilesMarc K Halushka
Jun 27, 2015·Cardiovascular Research·Justyna Fert-BoberJennifer E Van Eyk
Nov 3, 2015·The Journal of Rheumatology·Alma B PedersenMette Nørgaard
Nov 26, 2015·Clinical Epidemiology·Morten SchmidtHenrik Toft Sørensen
Oct 28, 2016·Arthritis & Rheumatology·Koray TascilarSamy Suissa
Mar 11, 2017·Journal of the American College of Cardiology·Ängla MantelJohan Askling
Dec 16, 2017·Journal of the American College of Cardiology·Brian B LøgstrupMichael Maeng

❮ Previous
Next ❯

Citations

Aug 31, 2019·Zeitschrift für Rheumatologie·Gernot Keyßer
May 8, 2020·Journal of the American Heart Association·Michael J AhlersDeepak K Gupta
Jun 5, 2020·Nature Reviews. Rheumatology·Anne Grete SembSilvia Rollefstad
Oct 1, 2019·Current Vascular Pharmacology·Iordanis S MourouzisConstantinos Pantos
Apr 13, 2020·JACC. Heart Failure·Sameer PrasadaMatthew J Feinstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.