PMID: 7528758Oct 1, 1994Paper

Development of hepatocellular carcinoma among patients with chronic liver disease due to hepatitis C viral infection

Journal of Clinical Gastroenterology
A M Di BisceglieJ H Hoofnagle

Abstract

Although chronic infection with hepatitis C (HCV) and B viruses (HBV) are important risk factors for hepatocellular carcinoma (HCC), their relative roles in causing liver cancer remain poorly defined, particularly in developed Western countries. Thirty-one patients with HCC seen at the Clinical Center of the National Institutes of Health between 1986 and 1992 were evaluated serologically for evidence of HBV and HCV infection: antibodies to HBV and HCV and hepatitis B surface antigen (HBsAg) were detected by conventional immunoassays, and HCV RNA and HBV DNA were detected by polymerase chain reaction (PCR). Serologic evidence of HBV infection was found in 18 patients (56%), 17 with antibodies, 16 with HBV DNA, and 14 with HBsAg. Evidence of HCV infection was found in 10 patients (32%), seven of whom also had HCV RNA. One patient had both anti-HCV and HBsAg. In comparison to patients with HBV-related HCC, those with HCV-related cancer were older and more likely to be white, to have been born in the United States, to have a history of parenteral exposure, and to have cirrhosis. In two patients in whom the course of hepatitis C could be traced from its onset, hepatocellular carcinoma developed after 5 years in one and after 9 years...Continue Reading

Citations

Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D V Sangar, A R Carroll
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·K A McGlynnJ F Fraumeni
Jan 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R SaxenaS N Thung
Jan 13, 2000·Biochemical and Biophysical Research Communications·J S ParkM K Min
Sep 29, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Amanda B CooperMary A Maluccio
Mar 11, 2005·Best Practice & Research. Clinical Gastroenterology·Charles Cha, Ronald P Dematteo
Sep 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·S SongsivilaiD Kanistanon
Jan 6, 1999·Journal of Hepatology·T StroffoliniG Gasbarrini
Jan 8, 1999·Research in Virology·M C Kew
May 11, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·E Tabor
May 8, 2001·Vox Sanguinis·F K Stevenson, W Rosenberg
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R BanerjeeR M Santella
Nov 27, 2002·Journal of Clinical Gastroenterology·Charles ChaLeslie H Blumgart
Sep 23, 2003·Annals of Surgery·Charles H ChaRonald P DeMatteo
Dec 7, 2013·World Journal of Gastroenterology : WJG·Yue Wang
Aug 8, 2012·Biochimica Et Biophysica Acta·Ioanna SevastouVassilis Aidinis
Feb 27, 2007·Seminars in Fetal & Neonatal Medicine·Björn Fischler
Jan 12, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wei YanAllan Tsung
May 27, 2008·The American Journal of Medicine·Robert Wong, Douglas A Corley
Oct 8, 2004·Journal of Biochemistry and Molecular Biology·Jung Su KimJinseu Park
Mar 15, 2014·Virulence·Urania GeorgopoulouAvgi Mamalaki
Apr 6, 2004·Clinics in Liver Disease·Richard H Moseley
Nov 1, 1996·Journal of Viral Hepatitis·Y NakatsujiH J Alter
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·R Olsson
Sep 23, 2003·The American Journal of Gastroenterology·Adrian M Di BisceglieUNKNOWN Liver Cancer Network
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karla J HelbigMichael R Beard
Aug 3, 2004·Nature Reviews. Immunology·Jukka Vakkila, Michael T Lotze
Dec 7, 2018·GigaScience·Weitai HuangCaroline G Lee
Jun 13, 2006·Proteomics·Motonari TakashimaKazuyuki Nakamura
Sep 15, 2006·Proteomics·Yasuhiro Kuramitsu, Kazuyuki Nakamura
Oct 16, 1999·The American Journal of Gastroenterology·N ChalasaniL Lumeng
Jul 4, 1998·The Journal of Biological Chemistry·T Y HsiehM M Lai

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