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Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice

Metallomics : Integrated Biometal Science

Nov 1, 2011

Yuji WangShiqi Peng

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Abstract

A series of chelants (3a-s) composed of a glucosyl tail, an amino acid side chain and a dithiocarbamate group were designed, synthesized, and evaluated. By co-administering with cisplatin, 3a-s were able to decrease the accumulation of platinum in the organs, maintain the accumulation o...read more

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NSC-119875
Amino Acid [EPC]
Entire Spleen
Antineoplastic Agents
Drug or Chemical Tissue Distribution
Weighing Patient
Organ
Cytoprotection
Platinum
Cisplatin
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Development of highly effective three-component cytoprotective adjuncts for cisplatin cancer treatment: synthesis and in vivo evaluation in S180-bearing mice

Metallomics : Integrated Biometal Science

Nov 1, 2011

Yuji WangShiqi Peng

PMID: 21584333

DOI: 10.1039/c1mt00013f

Abstract

A series of chelants (3a-s) composed of a glucosyl tail, an amino acid side chain and a dithiocarbamate group were designed, synthesized, and evaluated. By co-administering with cisplatin, 3a-s were able to decrease the accumulation of platinum in the organs, maintain the accumulation o...read more

Mentioned in this Paper

NSC-119875
Amino Acid [EPC]
Entire Spleen
Antineoplastic Agents
Drug or Chemical Tissue Distribution

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