Development of horizontal intrinsic connections in cat striate cortex

Experimental Brain Research
H. J. LuhmannW Singer

Abstract

Intracortical injections of horseradish peroxidase conjugated with wheat-germ agglutinin (WGA-HRP) reveal a characteristic patchy staining pattern within the superficial layers of cat striate cortex. The patches consist of a dense accumulation of labeled neurons and axonal arborizations. We have investigated the tangential organization and the development of these intrinsic cortical connections by using a flat-mount preparation of area 17. The diameter of the patches varied from 200 to 400 micron, the center-to-center distance ranged from 400 to 800 micron, and the spread of patches extended further in the anterior-posterior than in the medial-lateral direction. The expression of these horizontal patchy connections is age- and experience-dependent. From ten days to six weeks of age patches are exuberant and on occasion fuse to beaded bands extending radially from the injection site. From 6 weeks onwards the number and the tangential spread of the patches decreases to one or two rows of isolated clusters. Long-term binocular deprivation disrupts this pattern of intrinsic connections nearly completely. We infer from these results that there is an inborn pattern of discrete horizontal connections in striate cortex which is shaped ...Continue Reading

Citations

Sep 30, 1999·Journal of Neurobiology·B ChapmanT Bonhoeffer
Oct 1, 1990·Brain Research. Developmental Brain Research·S Löwel, W Singer
Aug 1, 1988·Neuroscience Research·B R PayneP Cornwell
Jul 1, 1992·Progress in Neurobiology·I FerrerC Auladell
Feb 1, 1996·Progress in Neurobiology·H J Luhmann
May 13, 2004·Visual Neuroscience·David M Coppola, Leonard E White
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E M Callaway, L C Katz
May 1, 1996·Network : Computation in Neural Systems·N V Swindale
Mar 9, 2011·Cerebral Cortex·Dylan Richard MuirRodney J Douglas
Jan 1, 1990·The European Journal of Neuroscience·H. J. LuhmannL. Martínez-Millán
Jan 1, 1990·The European Journal of Neuroscience·H. J. LuhmannW. Singer
Jun 1, 1996·The European Journal of Neuroscience·D Aggoun-AouaouiG M Innocenti
Aug 1, 1997·The European Journal of Neuroscience·I GödeckeW Singer
Jun 26, 2004·Annual Review of Neuroscience·Rodney J Douglas, Kevan A C Martin
Aug 9, 2001·The Journal of Comparative Neurology·P BuzásZ F Kisvárday
Aug 6, 2010·Progress in Neurobiology·Nicole VogesStefan Rotter
Nov 23, 2011·The European Journal of Neuroscience·Werner KilbHeiko J Luhmann
Jul 23, 2013·Neuroscience·R KhazipovG Valeeva
Sep 23, 1998·Experimental Neurology·M AlefeldH J Luhmann
Mar 1, 1997·Vision Research·U PolatA M Norcia
Jan 22, 2013·Neuroscience and Biobehavioral Reviews·Bjorn Merker
Dec 15, 2017·PLoS Computational Biology·Dylan R MuirBjörn M Kampa
Mar 20, 2015·Journal of Neurophysiology·Vicente Reyes-PuertaMaoz Shamir
Aug 1, 2015·The Journal of Comparative Neurology·Robert K NaumannMichael Brecht
Aug 24, 1999·The European Journal of Neuroscience·P D ZuffereyG M Innocenti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.