Development of hyperactivity and anxiety responses in dopamine transporter-deficient mice.

Developmental Neuroscience
Alex C CarpenterGregg D Stanwood

Abstract

Dopamine (DA) is a catecholamine neurotransmitter that regulates many aspects of motivated behavior in animals. Extracellular DA is highly regulated by the presynaptic high-affinity dopamine transporter (DAT), and drug- or genetically induced deficiencies in DAT function result in loss of DA reuptake. Mice in which DAT expression has been ablated have been previously proposed to be a relevant model of attention deficit hyperactivity disorder and have led to mechanistic insights regarding psychostimulant drug actions. However, very little previous work has emphasized the biobehavioral development of DAT-deficient mice. We therefore examined motoric, emotional and cognitive phenotypes in preadolescent (P22-26) DAT mutant mice. Consistent with previous reports in adult DAT(-/-) mice, we observed a hyperlocomotive phenotype in preadolescent mice across multiple assays. Somewhat surprisingly, spatial working memory in a Y-maze appeared intact, suggesting that cognitive phenotypes may emerge relatively late in development following hyperdopaminergia. Anxiety levels appeared to be reduced in DAT(-/-) mice, as defined by elevated plus maze and light-dark preference assays. No significant differences were observed between wild-type and ...Continue Reading

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Citations

Jul 19, 2012·Synapse·Catherine E KillingerGregg D Stanwood
May 13, 2015·Synapse·Devon L GrahamGregg D Stanwood
Apr 29, 2016·ACS Chemical Neuroscience·Michael F SalvatoreSara R Jones
Jun 4, 2016·Medical & Biological Engineering & Computing·Pınar KanlikilicerMetin Akay
Jan 30, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason R RichardsonGary W Miller
Feb 16, 2021·Frontiers in Pharmacology·Emma T van der WesthuizenArthur Christopoulos
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Fei Huang, Xiaojun Wu
Apr 18, 2021·Neurotoxicology and Teratology·Devon L GrahamGregg D Stanwood

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