PMID: 2508881Sep 16, 1989Paper

Development of hypertension and uraemia after pyelonephritis in childhood: 27 year follow up

BMJ : British Medical Journal
S H JacobsonJ Winberg

Abstract

Determination of the long term incidence of uraemia, hypertension, and toxaemia in pregnancy associated with non-obstructive focal renal scarring after pyelonephritis in childhood 25-35 years earlier. 27 Year follow up of patients with non-obstructive focal scarring identified from a retrospective review of intravenous urograms performed in childhood between 1951 and 1967. Paediatric primary referral centre and urological clinic in tertiary referral centre. 30 Patients (mean age 33 (range 22-41] with non-obstructive focal renal scarring first detected between 1951 and 1967 and a history of febrile urinary tract infection. Hypertension and complications of renal damage. Three patients had developed end stage renal disease, seven had developed hypertension, two of 16 women had a history of toxaemia during pregnancy, and seven patients had undergone renal surgery during follow up. Of the 20 patients who had neither had renal surgery nor had end stage renal disease, all had a significantly lower glomerular filtration rate and renal plasma flow and higher diastolic blood pressure, mean arterial blood pressure, plasma renin activity, and serum beta 2 microglobulin concentration than 13 healthy age matched controls. Diastolic blood pr...Continue Reading

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Citations

Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·S H JacobsonH E Wilczek
Jan 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S H JacobsonJ Winberg
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Jun 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jose Maria Penido SilvaEduardo Araujo Oliveira
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Feb 8, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ali ErTufan Nayir
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