PMID: 374889Jan 1, 1979Paper

Development of immune competence

Mechanisms of Ageing and Development
M L Tyan

Abstract

Present evidence indicates that the precursors of B- and T-cells can be found in the extra-embryonic tissues four days after implantation (day 5) and that by the following day (day 10) certain of the B-cell precursors have differentiated to the stage of the antigen-binding cell. Cells able to secrete antibody are not detected, however, until the later stages of pregnancy. B-cell differentiation has been shown to advance in a stepwise manner through several compartments, and the early stages of maturation are independent of thymic or T-cell regulation. The thymic rudiment appears by the 12th day of pregnancy and the reticuloepithelial tissue is quickly colonized by T-stem cells which migrate from the fetal liver. Within 4 days these cells respond to PHA, recognize and respond to allogeneic antigens, and begin to seed to the peripheral lymphoid tissues. During the latter stages of pregnancy and until about the sixth week after birth T-cell mediated suppressor activity predominates. T-cell killer function can be detected in the neonatal thymus shortly after birth, but this activity increases slowly in the peripheral lymphoid tissues. T-cell helper activity increases slowly after birth as suppressor activity declines. The adult lev...Continue Reading

References

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Citations

May 31, 1985·Mechanisms of Ageing and Development·G M Butenko, A I Kharazi
Jan 1, 1986·Journal of Toxicology and Environmental Health·R W LuebkeR J Smialowicz
Jul 18, 2014·Lung·Angel J Balam-MayMarco A Vega-López
Mar 13, 2014·Annual Review of Biochemistry·Christopher J Oldfield, A Keith Dunker
Aug 1, 1986·Acta Psychiatrica Scandinavica·L R GoldinE S Gershon

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