PMID: 9442296Jan 27, 1998Paper

Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention

Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement
K MacéA M Pfeifer

Abstract

Many natural dietary phytochemicals found compounds found in fruits, vegetables, spices and tea have been shown in recent years to be protective against cancer in various animal models. In the light of the potential impact of these compounds on human health it is important to elucidate the mechanisms involved. We therefore developed and characterized relevant in vitro models using immortalized human epithelial cell lines derived from target tissues in carcinogenesis, such as lung, liver and colon. Assays were established, allowing the evaluation of the cytotoxic and genotoxic effects of various procarcinogens, including nitrosamines, mycotoxins and heterocyclic amines on these metabolically-competent human epithelial cell lines. These cellular models appeared to be a useful tool to study the capacity of certain food components to block the initiation stage of carcinogenesis. The ability of carnosol and carnosic acid from rosemary as well as the synthetic dithiolethione, oltipraz, to block the formation of DNA adducts, and their effects on the expression of phase I and phase II enzymes was investigated. We have observed that both rosemary extracts and oltipraz inhibited benzo(a)pyrene- or aflatoxin B1-induced DNA adduct formatio...Continue Reading

Citations

Apr 14, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joseph SchwagerDaniel Raederstorff
Jul 8, 2009·Critical Reviews in Food Science and Nutrition·Ulf HammerlingNils-Gunnar Ilbäck
May 13, 2008·Journal of Food Protection·Arturo AnadónGuillermo Reglero
Apr 20, 2010·Journal of Agricultural and Food Chemistry·Naisheng BaiChi-Tang Ho

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