Development of inhalable curcumin loaded Nano-in-Microparticles for bronchoscopic photodynamic therapy

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Elias BaghdanUdo Bakowsky

Abstract

Photodynamic therapy is amongst the most rapidly developing therapeutic strategies against cancer. However, most photosensitizers are administered intravenously with very few reports about pulmonary applications. To address this issue, an inhalable formulation consisting of nanoparticles loaded with photosensitizer (i.e. curcumin) was developed. The nanoparticles were prepared using nanoprecipitation method. Dynamic light scattering measurements of the curcumin loaded nanoparticles revealed a hydrodynamic diameter of 181.20 ± 11.52 nm. In vitro irradiation experiments with human lung epithelial carcinoma cells (A549) showed a selective cellular toxicity of the nanoparticles upon activation using LED irradiating device. Moreover, curcumin nanoparticles exhibited a dose-dependent photocytotoxicity and the IC50 values of curcumin were directly dependent on the radiation fluence used. The nanoparticles were subsequently spray dried using mannitol as a stabilizer to produce Nano-in-Microparticles with appropriate aerodynamic properties for a sufficient deposition in the lungs. This was confirmed using the next generation impactor, which revealed a large fine particle fraction (64.94 ± 3.47%) and a mass median aerodynamic diameter of...Continue Reading

Citations

Apr 30, 2020·Mini Reviews in Medicinal Chemistry·Ayushi SethiyaShikha Agarwal
Oct 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giftson J SenapathyHeidi Abrahamse
Jul 4, 2020·Anti-cancer Agents in Medicinal Chemistry·Giftson J SenapathyHeidi Abrahamse
Nov 18, 2021·Homeopathy : the Journal of the Faculty of Homeopathy·Ayesha LoonatRahul Chandran

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