Development of inhalable nanocrystalline solid dispersion of tranilast for airway inflammatory diseases

Journal of Pharmaceutical Sciences
Satomi OnoueShizuo Yamada

Abstract

Tranilast (TL), an antiallergic agent, has been clinically used in the treatment of bronchial asthma, although the clinical use of TL is limited because of its poor solubility and systemic side effects. To overcome these drawbacks, a novel respirable powder (RP) of TL for inhalation therapy was developed using nanocrystal solid dispersion of TL (CSD/TL). In the CSD/TL, wet-milled crystalline TL particles with a mean diameter of 122 nm were dispersed, and there was a marked improvement in dissolution behavior of the CSD/TL-RP compared with that of a physical mixture of TL and carrier. Laser diffraction and cascade impactor analyses on the CSD/TL-RP demonstrated high dispersibility and deposition in the respiratory organs with emitted dose and fine particle fraction of ca. 98 and 60%, respectively. Inhaled CSD/TL-RP could attenuate antigen-induced inflammatory events in rats, as evidenced by histochemical analyses and inflammatory biomarkers such as lactate dehydrogenase, eosinophil peroxidase, and myeloperoxidase. The CSD/TL-RP seemed to be more potent than the physical mixture in inhibiting inflammatory responses, possibly due to the improved dissolution behavior. Systemic exposure of TL after intratracheal administration of CS...Continue Reading

References

Apr 1, 1986·The Journal of Allergy and Clinical Immunology·E Frigas, G J Gleich
Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
Aug 1, 1996·The European Respiratory Journal·M DrentM van Dieijen-Visser
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M BhatiaM L Steer
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P K Jeffery
Jan 6, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M Mosharraf, C Nyström
Nov 18, 2003·British Journal of Clinical Pharmacology·N R Labiris, M B Dolovich
Feb 16, 2008·Nature Reviews. Immunology·Peter J Barnes
May 21, 2008·Pulmonary Pharmacology & Therapeutics·Melanie Werner-KleinKlaus J Erb
Jan 1, 2007·Recent Patents on Drug Delivery & Formulation·Mahavir B ChouguleAmbikanandan Misra
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Shingen MisakaShizuo Yamada
Dec 30, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yohei KawabataShizuo Yamada

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Citations

Mar 6, 2012·Journal of Pharmaceutical Sciences·Yosuke AokiSatomi Onoue
Oct 13, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hong-Qian ChuXue-Tao Wei
Apr 24, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Satomi OnoueShizuo Yamada
Nov 24, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Satomi OnoueShizuo Yamada
Nov 18, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yohei KawabataShizuo Yamada
Feb 11, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Priya MuralidharanHeidi M Mansour
May 27, 2016·Pharmaceutical Research·Hideyuki SatoSatomi Onoue
Aug 20, 2016·Journal of Pharmaceutical Sciences·Hiroshi UedaYuichi Tozuka
Sep 11, 2019·Nanotoxicology·Nashwa M OsmanImran Y Saleem
Dec 14, 2018·Journal of Pharmaceutical Investigation·Young Hee Choi, Hyo-Kyung Han
Jun 26, 2020·Frontiers in Neuroscience·Saba NaqviS J S Flora
Mar 18, 2021·Lab on a Chip·Van T DauDzung V Dao
Jul 3, 2020·Current Pharmaceutical Design·Phuong H L Tran, Thao T D Tran
May 22, 2021·Immunopharmacology and Immunotoxicology·Ali Saeedi-BoroujeniAli Khodadadi
May 17, 2021·International Journal of Pharmaceutics·Vivek VermaLuis Padrela

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