PMID: 8598543Mar 1, 1996Paper

Development of insulin resistance in the rat is dependent on the rate of glucose absorption from the diet

The Journal of Nutrition
J A HigginsG S Denyer

Abstract

The effect of long-term consumption of diets of different carbohydrate composition was investigated be feeding rats for up to 52 wk on diets in which the carbohydrate was either glucose, amylose or amylopectin. A glucose-based diet was included to examine the relationship between the rate of carbohydrate absorption from the diet and the development of insulin resistance. Insulin sensitivity was assessed by subjecting animals to an intravenous glucose tolerance test (IVGTT). Amylopectin-fed animals became progressively insulin resistant from 12 to 26 wk of feeding. The area under the plasma insulin curves in response to a glucose load (IVGTT) for these animals rose progressively from 15.1 +/- 2.5 nmol/L.30 min at 8 wk to 45.8 +/- 3.5 nmol/L.30 min (P < 0.001) at 26 wk of feeding. Amylose-fed animals did not exhibit insulin resistance until 26 wk of feeding when insulin secretion in response to a glucose load was 28.3 +/- 0.9 vs. 14.6 +/- 3.2 nmol/L.30 min at 16 wk of feeding (P < 0.005). Glucose-fed animals displayed insulin resistance after only 8 wk of feeding. At this time, the area under their plasma insulin curves was almost double that for amylose- or amylopectin-fed animals (P < 0.001). We conclude that long-term consumpt...Continue Reading

Citations

Sep 18, 2003·The British Journal of Nutrition·Marc A BrownJanine A Higgins
May 10, 2016·Molecular Nutrition & Food Research·Pan Xi, Rui Hai Liu
Feb 1, 1997·The Journal of Nutrition·D Cameron-SmithG R Collier
Jul 13, 2000·The British Journal of Nutrition·L H StorlienP L Else
Jul 28, 2004·The American Journal of Clinical Nutrition·Matthias B SchulzeFrank B Hu
Feb 13, 2019·The Journal of Nutrition·Dalila Azzout-MarnichePatrick C Even
Feb 8, 2008·Bioscience, Biotechnology, and Biochemistry·Tomoyuki MishimaTakashi Hayakawa
Dec 3, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D B PawlakD S Ludwig
Jan 12, 2011·Current Diabetes Reports·Kate MarshJennie Brand-Miller
Nov 10, 2017·American Journal of Physiology. Endocrinology and Metabolism·Lewin SmallGregory J Cooney
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·L NoahM Champ
Jun 4, 2002·The Journal of Nutrition·L M GattoS Samman
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J C Mathers, M E Daly
Nov 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Evert M van SchothorstJaap Keijer
Apr 27, 2017·Nutrition Reviews·Gar Yee Koh, Matthew J Rowling
Jul 26, 2006·Journal of Animal Science·L G RileyP A Sheehy
Aug 7, 2010·Journal of Public Health Management and Practice : JPHMP·Jeanette HassinRobert S Young
Oct 5, 2001·The Journal of Nutrition·D H Bessesen
Jul 20, 2002·The International Journal of Biochemistry & Cell Biology·Vanderlei FolmerJ B T Rocha
Apr 11, 2006·Biomacromolecules·Xian-Zhong HanBruce R Hamaker

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