Development of K(+) and Na(+) conductances in rodent postnatal semicircular canal type I hair cells.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Gang Q LiKatherine J Rennie

Abstract

The rodent vestibular system is immature at birth. During the first postnatal week, vestibular type I and type II hair cells start to acquire their characteristic morphology and afferent innervation. We have studied postnatal changes in the membrane properties of type I hair cells acutely isolated from the semicircular canals (SCC) of gerbils and rats using whole cell patch clamp and report for the first time developmental changes in ionic conductances in these cells. At postnatal day (P) 5 immature hair cells expressed a delayed rectifier K(+) conductance (G(DR)) which activated at potentials above approximately -50 mV in both species. Hair cells also expressed a transient Na(+) conductance (G(Na)) with a mean half-inactivation of approximately -90 mV. At P6 in rat and P7 in gerbil, a low-voltage activated K(+) conductance (G(K,L)) was first observed and conferred a low-input resistance, typical of adult type I hair cells, on SCC type I hair cells. G(K,L) expression in hair cells increased markedly during the second postnatal week and was present in all rat type I hair cells by P14. In gerbil hair cells, G(K,L) appeared later and was present in all type I hair cells by P19. During the third postnatal week, G(Na) expression dec...Continue Reading

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Citations

Nov 8, 2011·The Journal of Membrane Biology·Frances L MeredithKatherine J Rennie
Jun 20, 2014·Journal of the Association for Research in Otolaryngology : JARO·Rebecca LimAlan M Brichta
Apr 8, 2011·Annual Review of Neuroscience·Ruth Anne Eatock, Jocelyn E Songer
Feb 3, 2016·Hearing Research·Frances L Meredith, Katherine J Rennie
Mar 17, 2017·Journal of Neurophysiology·Matthew E KirkKatherine J Rennie
Dec 20, 2018·Journal of Neurophysiology·R D Rabbitt
Oct 25, 2014·Journal of Neurophysiology·Frances L Meredith, Katherine J Rennie
Jul 2, 2020·Journal of Neurophysiology·Zhou YuElisabeth Glowatzki
Nov 30, 2018·Frontiers in Cellular Neuroscience·Frances L Meredith, Katherine J Rennie

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