Development of K-doped ZnO nanoparticles encapsulated crosslinked chitosan based new membranes to stimulate angiogenesis in tissue engineered skin grafts

International Journal of Biological Macromolecules
Lubna ShahzadiMuhammad Yar

Abstract

Nanoparticles are well recognized for their biological applications including tissue-regeneration due to large surface area and chemical properties. In this study, K-doped zinc oxide (ZnO) nanoparticles containing porous hydrogels were synthesized via freeze gelation. The morphology and pore dimensions were studied by scanning electron microscopy (SEM). The chemical structural analysis of the synthesized hydrogels was investigated by Fourier Transform Infrared (FTIR) spectroscopy. In swelling studies, material containing ZnO nanoparticles with 2% potassium dopant concentration CLH-K2.0) showed greater degree of swelling as compared to all other materials. The degradation studied was tested in three different degradation media, i.e. phosphate buffer saline (PBS), lysozyme and hydrogen peroxide and relatively higher degradation was seen in hydrogen peroxide. The synthesized hydrogels were implanted on the chick chorioallantoic membrane (CAM) to investigate their angiogenic potential. The CLH-K2.0 hydrogel stimulated angiogenesis greater than all other materials; blood vessels were attached and grown inside this scaffold, showing its strong angiogenic potential.

References

Jul 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·John StreetEllen H Filvaroff
Sep 18, 2002·The Journal of Clinical Investigation·Hairong PengJohnny Huard
Feb 1, 2003·International Journal of Biological Macromolecules·M L DuarteJoão Rocha
Mar 15, 2006·Biomaterials·Frank A MüllerRainer Staudenmaier
Nov 6, 2007·Progress in Histochemistry and Cytochemistry·Sabine A EmingManuel Koch
Jan 12, 2010·Acta Biomaterialia·Magdalena ZaborowskaPaul Gatenholm
Aug 19, 2010·Expert Opinion on Drug Delivery·John W RasmussenDenise G Wingett
Nov 3, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Mariappan PremanathanGovindasamy Manivannan
Nov 9, 2012·Pharmaceutical Research·Sudheesh Kumar P TRangasamy Jayakumar
Nov 16, 2012·Nanoscale·Ayan Kumar BaruiChitta Ranjan Patra
Oct 19, 2013·The Analyst·Thiago M PereiraMax Diem
Nov 12, 2013·Current Molecular Medicine·Y ZhangW Cai
May 15, 2015·Acta Biomaterialia·Saad B QasimIhtesham Ur Rehman
Aug 8, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Ariba FarooqIhtesham ur Rehman
Apr 30, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Muhammad YarIhtesham Ur Rehman
Sep 1, 2008·Science and Technology of Advanced Materials·Nagarajan Padmavathy, Rajagopalan Vijayaraghavan
Mar 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Muhammad YarSheila MacNeil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.