Development of Liposomal Formulation for Delivering Anticancer Drug to Breast Cancer Stem-Cell-Like Cells and its Pharmacokinetics in an Animal Model

Molecular Pharmaceutics
Ajaz AhmadKhalid M Alkharfy

Abstract

The objective of the present study is to develop a liposomal formulation for delivering anticancer drug to breast cancer stem-cell-like cells, ANV-1, and evaluate its pharmacokinetics in an animal model. The anticancer drug ESC8 was used in dexamethasone (Dex)-associated liposome (DX) to form ESC8-entrapped liposome named DXE. ANV-1 cells showed high-level expression of NRP-1. To enhance tumor regression, we additionally adapted to codeliver the NRP-1 shRNA-encoded plasmid using the established DXE liposome. In vivo efficacy of DXE-NRP-1 was carried out in mice bearing ANV-1 cells as xenograft tumors and the extent of tumor growth inhibition was evaluated by tumor-size measurement. A significant difference in tumor volume started to reveal between DXE-NRP-1 group and DXE-Control group. DXE-NRP-1 group showed ∼4 folds and ∼2.5 folds smaller tumor volume than exhibited by untreated and DXE-Control-treated groups, respectively. DXE disposition was evaluated in Sprague-Dawley rats following an intraperitoneal dose (3.67 mg/kg of ESC8 in DXE). The plasma concentrations of ESC8 in the DXE formulation were measured by liquid chromatography mass spectrometry and pharmacokinetic parameters were determined using a noncompartmental analys...Continue Reading

References

May 1, 1995·British Journal of Haematology·I D ChantA G Morris
Feb 22, 2002·Chemistry : a European Journal·Rajkumar Sunil SinghNalam Madhusudhana Rao
Sep 30, 2003·The Journal of Biological Chemistry·Ling WangDebabrata Mukhopadhyay
Sep 22, 2005·Nature Reviews. Cancer·Luke Whitesell, Susan L Lindquist
Nov 23, 2006·International Journal of Pharmaceutics·Kuntal MaitiPulok K Mukherjee
Apr 6, 2007·Cancer Research·Elah PickHarriet M Kluger
Jul 25, 2007·Annual Review of Cell and Developmental Biology·Neethan A LoboMichael F Clarke
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tse-Ming HongPan-Chyr Yang
Nov 27, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M M McCarthyH M Kluger
Mar 22, 2008·Current Opinion in Genetics & Development·Robert W Cho, Michael F Clarke
Feb 19, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Amarnath MukherjeeRajkumar Banerjee
Feb 17, 2010·Current Clinical Pharmacology·Kunal ChaudharyChris Papageorgio
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 19, 2013·Biomaterials·Subrata Kumar PoreRajkumar Banerjee

❮ Previous
Next ❯

Citations

May 6, 2016·Frontiers in Pharmacology·Bing LuWei Zhao
Sep 30, 2016·Frontiers in Pharmacology·Lili HeJingxin Mo
Feb 6, 2017·Frontiers in Pharmacology·Weiwei QinYuanqing Zhang
Jul 4, 2020·Nanomedicine·Sai Kiran Ss PindiproluPavan Kumar Chintamaneni
Jun 6, 2020·Nanotechnology·Xiaofeng DaiKostya Ken Ostrikov
Feb 4, 2021·Acta Pharmaceutica Sinica. B·Hongxia DuanWei Huang
Dec 24, 2019·Seminars in Cancer Biology·Mohammed Razeeth Shait MohammedMohammad Imran Khan
Apr 5, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tuying YongXiangliang Yang
Sep 21, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Namita MahadikRajkumar Banerjee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Related Papers

Journal of Veterinary Pharmacology and Therapeutics
I A AljuffaliR D Arnold
Antimicrobial Agents and Chemotherapy
M X QianJ M Gallo
Research Communications in Chemical Pathology and Pharmacology
L J BrunnerD R Luke
© 2021 Meta ULC. All rights reserved