Development of lymphatic vasculature and morphological characterization in rat kidney.

Clinical and Experimental Nephrology
Maki TanabeYuh Fukuda

Abstract

The mechanisms and morphological characteristics of lymphatic vascular development in embryonic kidneys remain uncertain. We examined the distribution and characteristics of lymphatic vessels in developing rat kidneys using immunostaining for podoplanin, prox-1, Ki-67, type IV collagen (basement membrane: BM), and α-smooth muscle actin (αSMA: pericytes or mural cells). We also examined the expression of VEGF-C. At embryonic day 17 (E17), podoplanin-positive lymphatic vessels were observed mainly in the kidney hilus. At E20, lymphatic vessels extended further into the developing kidneys along the interlobar vasculature. In 1-day-old pups (P1) to P20, lymphatic vessels appeared around the arcuate arteries and veins of the kidneys, with some reaching the developing cortex via interlobular vessels. In 8-week-old adult rats, lymphatic vessels were extensively distributed around the blood vasculature from the renal hilus to cortex. Only lymphatic capillaries lacking continuous BM and αSMA-positive cells were present within adult kidneys, with none observed in renal medulla. VEGF-C was upregulated in the developing kidneys and expressed mainly in tubules. Importantly, the developing lymphatic vessels were characterized by endothelial ...Continue Reading

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Citations

Sep 26, 2014·Expert Reviews in Molecular Medicine·Saleh YazdaniJacob van den Born
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Feb 1, 2019·Pediatric Research·Kee Hwan YooYoung Sook Hong
Jun 24, 2021·Nature Reviews. Nephrology·Michael D DonnanSusan E Quaggin

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