PMID: 7537511Jan 1, 1995Paper

Development of lymphoid hyperplasia in transgenic mice expressing the HIV tat gene

AIDS Research and Human Retroviruses
C VellutiniP Filippi

Abstract

During HIV infection, individuals experience multiorgan disorders such as adenopathy, splenomegaly, and lung and brain diseases. There is an increasing body of evidence that the HIV trans-activating tat gene product possesses multiple activities. First, it can activate several cellular genes; second, in its extracellular soluble form, it plays the role of growth factor in some cells such as Kaposi's sarcoma cells. Thus, we introduced the HIV tat gene, under the control of the cellular proteolipoprotein promoter, into the germline of mice and demonstrate that, when expressed, the tat gene product induces lymphoid hyperplasia in spleen, lymph nodes, and lung, as is observed in AIDS patients, but not in the brain or testes. Our findings indicate that HIV, through some of its genes, directly participates in the pathogenesis of AIDS.

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Citations

Jan 23, 1999·Journal of Immunological Methods·D GibelliniG Zauli
Nov 30, 2002·Virus Research·Davide GibelliniGiorgio Zauli
Mar 22, 2001·British Journal of Haematology·D GibelliniG Zauli
Jul 1, 1997·The Journal of Clinical Investigation·B T TinkleG Jay
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·S S CohenD I Cohen
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·W ReidJ Bryant
May 10, 2018·Journal of Translational Medicine·Yanan JiangYunlong Bai
Feb 28, 2003·Clinical and Experimental Immunology·D GibelliniG Zauli
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hava Karsenty AvrahamShalom Avraham
Sep 15, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Haijun HanMing D Li
Jan 26, 2011·Journal of the International AIDS Society·Filiberto Cedeno-LaurentJose R Trujillo
Dec 10, 2020·International Journal of Molecular Sciences·Dörthe MasemannYvonne Boergeling

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