Development of mannosylated liposomes using synthesized N-octadecyl-D-mannopyranosylamine to enhance gastrointestinal permeability for protein delivery.

AAPS PharmSciTech
Wasu WitoonsaridsilpNarong Sarisuta

Abstract

The lysozyme (LZ)-entrapped mannosylated liposomes were prepared in this study by the use of N-octadecyl-D-mannopyranosylamine (SAMAN), which had been synthesized in-house and confirmed by characterization with FTIR and NMR. The reactant residues of synthesized SAMAN were found to be less than 1%. The mean sizes, zeta potentials, drug entrapment efficiencies, and loading capacities of all liposomal formulations were in the ranges of 234.7 to 431.0 nm, -10.97 to -25.80 mV, 7.52 to 14.10%, and 1.44 to 2.77%, respectively. The permeability of mannosylated LZ liposomes across Caco-2 cell monolayers was significantly enhanced to about 2.5- and 7-folds over those of conventional liposomes and solution, respectively, which might be due to the role of mannose receptor or mannose-binding protein on the intestinal enterocytes.

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Citations

Apr 14, 2016·Nanomedicine·Thanh Xuan NguyenQun Wang
Nov 8, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Panita SuwannoiChristel C Müller-Goymann
Sep 28, 2018·PloS One·Jordan D LewickyHoang-Thanh Le
Jun 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·D GoyardR Roy
Nov 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Thanh Xuan NguyenGuang Yang
Oct 31, 2018·Open Life Sciences·Agnieszka Pudlarz, Janusz Szemraj

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