Development of meniscus substitutes using a mixture of biocompatible polymers and extra cellular matrix components by electrospinning

Materials Science & Engineering. C, Materials for Biological Applications
G López-CalzadaM Estevez

Abstract

Despite the significant advances in the meniscus tissue engineering field, it is difficult to recreate the complex structure and organization of the collagenous matrix of the meniscus. In this work, we developed a meniscus prototype to be used as substitute or scaffold for the regeneration of the meniscal matrix, recreating the differential morphology of the meniscus by electrospinning. Synthetic biocompatible polymers were combined with the extracellular matrix component, collagen and used to replicate the meniscus. We studied the correlation between mechanical and structural properties of the polymer blend as a function of collagen concentration. Fibers were collected on a surface of a rapidly rotating precast mold, to accurately replicate each sectional morphology of the meniscus; different electro-tissues were produced. Detailed XRD analyses exhibited structural changes developed by electrospinning. We achieved to integrate all these electro-tissues to form a complete synthetic meniscus. Vascularization tests were performed to assess the potential use of our novel polymeric blend for promising meniscus regeneration.

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Citations

Jan 9, 2018·Journal of Biomaterials Science. Polymer Edition·Mingxue ChenTingfei Xi
Sep 26, 2020·Nanomedicine·Shawn P GroganDarryl D D'Lima
Mar 23, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Sonia BansalJay M Patel
Apr 21, 2021·The Journal of the American Academy of Orthopaedic Surgeons·Ashley B AndersonJonathan F Dickens
Oct 8, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Xiaoyu WangJinglei Wu

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