Feb 14, 2013

Development of metabolic syndrome components in adults with a healthy obese phenotype: a 3-year follow-up

C den EngelsenG E Rutten


There is a lack of data on the progression from a healthy obese phenotype toward an unhealthy obese phenotype and the development of metabolic syndrome (MetS). Our aim was to assess the development of MetS 3 years after screening in centrally obese individuals with a healthy obese phenotype and to evaluate the usefulness of repeated screening. Eighty-eight individuals (mean age 47 years, 88% female) with central obesity as their only MetS component (ATP III criteria) at baseline screening were re-evaluated for MetS status after 3 years. At follow-up, the cardiometabolic risk profile in centrally obese individuals with a healthy phenotype showed a tendency toward deterioration. Thirty-two percent developed at least one additional MetS component, 7% had developed MetS. Nobody had developed type 2 diabetes. An increased triglyceride level (n = 16) and an increased blood pressure (n = 18) were the components most often present at follow-up. The people developing additional MetS components had a lower education level compared with the group that preserved the healthy centrally obese phenotype (80 vs. 71% lower educated, P = 0.35). They also had slightly worse baseline levels of the risk factors. The number of centrally obese individ...Continue Reading

Mentioned in this Paper

Diabetes Mellitus, Non-Insulin-Dependent
Diastolic Blood Pressure
Obesity, Visceral
Cardiovascular Diseases
Metabolic Syndrome X
Biologic Preservation
Population Surveillance
Hypertensive Disease

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