Development of Microemulsion Based Nabumetone Transdermal Delivery for Treatment of Arthritis

Recent Patents on Drug Delivery & Formulation
Swati C JagdaleAnuruddha R Chabukswar

Abstract

Nabumetone is biopharmaceutics classification system (BCS) class II drug, widely used in the treatment of osteoarthritis and rheumatoid arthritis. The most frequently reported adverse reactions for the drug involve disturbance in gastrointestinal tract, diarrhea, dyspepsia and abdominal pain. Microemulgel has advantages of microemulsion for improving solubility for hydrophobic drug. Patent literature had shown that the work for drug has been carried on spray chilling, enteric coated tablet, and topical formulation which gave an idea for present research work for the development of transdermal delivery. The objective of the present research work was to optimize transdermal microemulgel delivery for Nabumetone for the treatment of arthritis. Oil, surfactant and co-surfactant were selected based on solubility study of the drug. Gelling agents used were Carbopol 934 and HPMC K100M. Optimization was carried out using 32 factorial design. Characterization and evaluation were carried out for microemulsion and microemulsion based gel. Field emission-scanning electron microscopy (FE-SEM) study of the microemulsion revealed globules of 50-200 nm size. Zeta potential -9.50 mV indicated good stability of microemulsion. Globule size measure...Continue Reading

Citations

Oct 2, 2020·Advances in Colloid and Interface Science·Tahani SaeediPolina Prokopovich
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fedora GrandeAntonio Garofalo
Oct 6, 2021·Drug Delivery and Translational Research·Mori DhavalRamesh Parmar

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