Development of microporous drug-releasing films cast from artificial nanosized latexes of poly(styrene-co-methyl methacrylate) or poly(styrene-co-ethyl methacrylate)

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Daniel P OttoMelgardt M de Villiers

Abstract

Two sets of copolymers comprising of styrene and either methyl or ethyl methacrylate as comonomer were conveniently synthesized by microemulsion copolymerization. The purified materials were characterized by GPC-MALLS and were shown to form artificial nanolatexes in THF. ATR-FTIR analysis revealed differences in copolymer composition and based on the copolymer properties, a selection of copolymers was chosen to cast drug-loaded, microporous films that exhibit microencapsulation of drug agglomerates. The contact angles of the copolymers suggested potential applications in medical devices to prevent the formation of bacterial biofilms that commonly result in infections. Additionally, the different copolymeric films showed two phases of drug release characterized by a rapid initial drug release followed by a zero-order phase. Depending on the application, one could select the copolymer films that best suited the application i.e. for short-term drug release applications such as urinary catheters or long-term applications such as artificial implants.

Citations

Nov 23, 2012·International Journal of Nanomedicine·N AshwanikumarGs Vinod Kumar
Sep 9, 2015·Scientific Reports·Estefânia Vangelie Ramos CamposLeonardo Fernandes Fraceto
Apr 3, 2019·Environmental Science and Pollution Research International·Chan ZhangLiangqi Zhao
May 9, 2019·Applied Microbiology and Biotechnology·Bruna Cambraia GarmsRondinelli Donizetti Herculano

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