Abstract
Minimal-change glomerular disease, sarcoidosis and autoimmune thyroid disease rarely occur in the same patient. We herein report a patient in which minimal-change glomerular disease and Hashimoto's thyroiditis developed during the treatment of sarcoidosis with steroids. A 66-year-old female was admitted to our hospital with symptoms of nephrotic syndrome. Nine months before admission, she was diagnosed as having ocular and pulmonary sarcoidosis, for which prednisolone at an initial dose of 40 mg/day was started. When the dose of prednisolone was tapered to 20 mg/day, she noticed swelling of the lower extremities. Examination confirmed the simultaneous occurrence of minimal-change glomerular disease and Hashimoto's thyroiditis, which were diagnosed based on kidney histology, ultrasonography of the thyroid gland and positive antithyroglobulin antibodies. We used intravenous methylprednisolone pulse therapy followed by 40 mg/day oral prednisolone. The patient achieved complete remission of nephrotic syndrome and steroids were tapered without relapse.
References
May 1, 1982·British Medical Journal·R G TaylorB I Hoffbrand
Jan 1, 1993·Nephron·N Anwar, R Gokal
Mar 1, 1996·European Journal of Endocrinology·K I PapadopoulosB Hallengren
May 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E MündleinE Ritz
Apr 1, 1997·Clinical Endocrinology·H NakamuraT Yoshimi
Nov 14, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R G Parry, C Falk
Feb 19, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B A BeckerN A Breslau
Jul 7, 1999·American Journal of Nephrology·S KagiyamaK Onoyama
Nov 28, 2000·American Journal of Nephrology·A NishimotoN Yonemitsu
Mar 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Steve HoltPaul Sweny
Apr 10, 2002·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Lal K TanwaniSri Prakash L Mokshagundam
Jan 25, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Philippe GrimbertDjillali Sahali
Jul 14, 2004·Neuroimmunomodulation·Costas PhenekosMichael Papamichail
Jul 22, 2004·Annals of the New York Academy of Sciences·Ilia J Elenkov
Aug 11, 2006·Chest·Alessandro AntonelliEle Ferrannini
Jan 26, 2008·Clinical Nephrology·Y IwazuE Kusano
Dec 18, 2009·The Journal of Clinical Endocrinology and Metabolism·Nicté Figueroa-VegaMónica Marazuela
Dec 9, 2010·Thorax·Monica FaccoCarlo Agostini
Apr 1, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Li-Li LiuXue-Wang Li