Development of modified HCH-1 kinetic model for long-term enzymatic cellulose hydrolysis and comparison with literature models

Biotechnology for Biofuels
Chao LiangMark T Holtzapple

Abstract

Enzymatic hydrolysis is a major step for cellulosic ethanol production. A thorough understanding of enzymatic hydrolysis is necessary to help design optimal conditions and economical systems. The original HCH-1 (Holtzapple-Caram-Humphrey-1) model is a generalized mechanistic model for enzymatic cellulose hydrolysis, but was previously applied only to the initial rates. In this study, the original HCH-1 model was modified to describe integrated enzymatic cellulose hydrolysis. The relationships between parameters in the HCH-1 model and substrate conversion were investigated. Literature models for long-term (> 48 h) enzymatic hydrolysis were summarized and compared to the modified HCH-1 model. A modified HCH-1 model was developed for long-term (> 48 h) enzymatic cellulose hydrolysis. This modified HCH-1 model includes the following additional considerations: (1) relationships between coefficients and substrate conversion, and (2) enzyme stability. Parameter estimation was performed with 10-day experimental data using α-cellulose as substrate. The developed model satisfactorily describes integrated cellulose hydrolysis data taken with various reaction conditions (initial substrate concentration, initial product concentration, enzym...Continue Reading

References

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Citations

Jul 25, 2019·Biotechnology for Biofuels·Chao LiangMark Holtzapple
May 12, 2020·Frontiers in Bioengineering and Biotechnology·Estephanie Laura Nottar EscobarLuiz Pereira Ramos
May 26, 2020·Bioscience, Biotechnology, and Biochemistry·Feng LiuXu-Hui Li
May 6, 2021·Scientific Reports·Joseph Mcgreg DuruCristian Eugen Răducanu

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Software Mentioned

MATLAB

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