Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing

International Journal of Pharmaceutics
Alvaro GoyanesAbdul W Basit

Abstract

The aim of this study was to manufacture 3D printed tablets (printlets) from enteric polymers by single filament fused deposition modeling (FDM) 3D printing (3DP). Hot melt extrusion was used to generate paracetamol-loaded filaments from three different grades of the pharmaceutical excipient hypromellose acetate succinate (HPMCAS), grades LG, MG and HG. One-step 3DP was used to process these filaments into enteric printlets incorporating up to 50% drug loading with two different infill percentages (20 and 100%). X-ray Micro Computed Tomography (Micro-CT) analysis revealed that printlets with 20% infill had cavities in the core compared to 100% infill, and that the density of the 50% drug loading printlets was higher than the equivalent formulations loaded with 5% drug. In biorelevant bicarbonate dissolution media, drug release from the printlets was dependent on the polymer composition, drug loading and the internal structure of the formulations. All HPMCAS-based printlets showed delayed drug release properties, and in the intestinal conditions, drug release was faster from the printlets prepared with polymers with a lower pH-threshold: HPMCAS LG > HPMCAS MG > HPMCAS HG. These results confirm that FDM 3D printing makes it possi...Continue Reading

Citations

Feb 13, 2019·Drug Development and Industrial Pharmacy·Pan TianYan-Zhong Chen
Feb 9, 2018·Journal of Drug Targeting·Derfogail DelcassianRobert Langer
Apr 23, 2019·Expert Opinion on Drug Delivery·Venkata Raman KallakuntaMichael A Repka
Jan 15, 2020·Drug Development and Industrial Pharmacy·Emad NaseriAli Ahmadi
Aug 30, 2019·Scientific Reports·Xiaowen XuJunliang Yang
Mar 8, 2020·Journal of Personalized Medicine·Ilhan Yu, Roland K Chen
Apr 5, 2018·Pharmaceutics·Evert FuenmayorIan Major
Jul 13, 2018·Pharmaceutical Research·Witold JamrózRenata Jachowicz
Jan 15, 2019·Current Pharmaceutical Design·Mohammed S AlgahtaniJaved Ahmad
Jul 25, 2019·Current Pharmaceutical Design·Anish ChandekarGaurav Gupta
Jul 4, 2020·Drug Development and Industrial Pharmacy·Eleftherios G AndriotisDimitrios G Fatouros
Aug 7, 2019·Pharmaceutics·Andrew Kjar, Yu Huang
Jul 9, 2020·Pharmaceutics·Ángela Aguilar-de-LeyvaIsidoro Caraballo
Sep 6, 2019·Biotechnology Journal·Qingzhen YangFeng Xu
Dec 7, 2018·Current Pharmaceutical Design·Ilias El AitaJulian Quodbach
Aug 14, 2020·Polymers·Fabrizio FinaAbdul W Basit
Oct 30, 2020·Journal of Medical Engineering & Technology·Debojit Bhattacharjee, Vivek Srivastava
Sep 26, 2020·Journal of Pharmaceutical Sciences·Ogochukwu Lilian Okafor-MuoAmr ElShaer
Sep 7, 2020·International Journal of Pharmaceutics·R Durga Prasad Reddy, Varun Sharma
Oct 10, 2020·Journal of Pharmaceutical Sciences·Manjusha AnnajiR Jayachandra Babu
Jan 26, 2021·Drug Development and Industrial Pharmacy·Ukti BhattSubham Banerjee
Feb 5, 2021·International Journal of Pharmaceutics·Kejing ShiAli Nokhodchi
Jan 29, 2021·Pharmaceutics·Alperen AbaciMurat Guvendiren
Feb 12, 2021·Advanced Drug Delivery Reviews·Suresh BandariMichael A Repka

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