Development of movement-related intracortical inhibition in acute to chronic subcortical stroke

Neurology
Gianpiero LiuzziFriedhelm C Hummel

Abstract

A prospective longitudinal cohort study in stroke patients was performed to better understand the role of γ-aminobutyric acid-dependent intracortical inhibition (ICI) for recovery after stroke. Patients with acute first-ever subcortical stroke and hand paresis were recruited, and motor function as well as ICI were measured up to 1 year after stroke. Motor recovery was defined as the change in hand motor function from the acute to the chronic stage (Δ = recovery over 1 year). Primary outcome measures for hand motor function were the recovery of grip strength (ΔGS) and finger-tapping speed (ΔFT). Using double-pulse transcranial magnetic stimulation, we studied ICI in the ipsilesional primary motor cortex during the preparation of a movement with the paretic hand at different time points during recovery (first week, 7 weeks, 3 months, and 1 year after stroke). Eleven patients were enrolled (mean age 62.9 ± 3.8 years). The results of a multiple regression analysis showed a significant association of movement-related ICI in the acute stage only (first week) with motor recovery over 1 year (ΔGS: R(2) = 0.75, F = 17.6, p = 0.006; ΔFT: R(2) = 0.55, F = 7.3, p = 0.035). More disinhibition of ICI in the acute phase of stroke predicted mo...Continue Reading

Citations

Mar 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·George F Wittenberg, Michael A Dimyan
Aug 6, 2014·Neuroscience·V Bachtiar, C J Stagg
Oct 3, 2014·Experimental & Translational Stroke Medicine·Fanny Quandt, Friedhelm C Hummel
Feb 26, 2019·Annals of Neurology·Jing XuUNKNOWN SMARTS Study Group
Jul 2, 2019·Brain : a Journal of Neurology·Martina CosciaFriedhelm C Hummel
Mar 19, 2020·Journal of Neurophysiology·John CirilloWinston D Byblow
Apr 13, 2018·Frontiers in Neurology·Cintya Yukie HayashiWellingson Silva Paiva
Jan 5, 2019·Experimental Brain Research·Na Jin SeoTibor Nagy
Jul 28, 2020·Neural Plasticity·Nathan W KongMatthew C Tate
Jan 21, 2021·Scientific Reports·Maximilian J WesselFriedhelm C Hummel
Feb 23, 2020·Neuron·Silvestro MiceraAlessandra Pedrocchi
Jul 9, 2021·Brain : a Journal of Neurology·Philipp J KochFriedhelm C Hummel

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