Development of mucoadhesive films for buccal administration of flufenamic acid: Effect of cyclodextrin complexation

Journal of Pharmaceutical Sciences
Paola MuraMarco Bragagni

Abstract

A new mucoadhesive film for topical administration in the oral cavity of flufenamic acid, a poorly soluble anti-inflammatory drug, has been developed, using complexation with hydroxypropyl-beta-cyclodextrin (HPbetaCD) to improve drug dissolution and release rate. Buccal films were prepared utilising chitosan as mucoadhesive polymer, KollicoatIR as film-forming polymer and glycerol as plasticiser. Different combinations of these components were used and the obtained films were characterised for weight, thickness, swelling, mucoadhesive and mechanical properties. The film containing chitosan 2%, glycerol 7.5% and KollicoatIR 1% showed the best properties for the development of the film formulation. The selected film was loaded with the plain drug and its colyophilised and coground products with HPbetaCD, and in vitro release studies in simulated saliva were performed. The improved drug dissolution properties, obtained by complexation with HPbetaCD, were critical to achieve complete release from film formulation during 4-5 h. On the contrary, film loaded with the plain drug showed incomplete release, not exceeding 70% release after 5 h. The developed film formulation containing the drug as complex with HPbetaCD can assure a prolon...Continue Reading

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Citations

Sep 29, 2011·AAPS PharmSciTech·Paulo José SalústioHelena M Cabral Marques
Dec 12, 2012·AAPS PharmSciTech·Daniel A RealDarío Leonardi
Jul 7, 2011·International Journal of Molecular Sciences·Urszula DomańskaAneta Pobudkowska
Aug 4, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pallavi Bassi, Gurpreet Kaur
Aug 11, 2011·The Journal of Pharmacy and Pharmacology·Thorsteinn Loftsson, Marcus E Brewster
Jun 15, 2014·International Journal of Pharmaceutics·Kris HermansAnnick Ludwig
Mar 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ana Filipa BorgesSérgio Simões
Sep 7, 2018·Drug Development Research·Shery Jacob, Anroop B Nair
Jan 16, 2018·Pharmaceutical Development and Technology·Chengliang ZhangDong Liu
Sep 4, 2015·Journal of Nanotechnology in Engineering and Medicine·Manijeh GoldbergRobert Langer
Jun 12, 2013·Biomaterials Science·Sandeep K RamineniDavid A Puleo
Jul 2, 2020·International Journal of Nanomedicine·Tarek A AhmedMartin K Safo

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