Development of mucoadhesive thio-carboxymethyl cellulose for application in buccal delivery of drugs

Therapeutic Delivery
Flavia Laffleur, Alexie Messirek

Abstract

L-cysteine (CYS) was covalently attached to carboxymethyl cellulose (CMC) to obtain the thiolated conjugate CMCCYS. Methodology & results: CMCCYS and controls were investigated in terms of safety, disintegration, erosion and mucoadhesiveness. Furthermore, mechanical, physicochemical properties, mucoadhesive strength, swelling behavior and residence time were evaluated. Exhibiting 99.61 ± 2.51% cell viability, CMCCYS was considered as non toxic at all. Furthermore, CMCCYS displayed 2.8-fold higher polymer stability as well as 5.8-fold less erosion than unmodified CMC. Mucoadhesive strength assay displayed 1.6-fold improved adhesion on buccal mucosa as well as 2.7-fold improved mucoadhesiveness on the rotating cylinder. Chemical modification of well-known CMC encourage further evaluation and application of the mucoadhesive potential for the buccal delivery.

References

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Citations

Jan 16, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Flavia LaffleurAndreas Bernkop-Schnürch
Jul 5, 2017·Macromolecular Bioscience·Philipp SchattlingBrigitte Städler
May 8, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Soeun GimMartina Delbianco
Jan 10, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ana S MacedoPedro Fonte
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Danielle M Beaupre, Richard G Weiss
Dec 1, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bengi ÖzkahramanAyça Bal-Öztürk

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Methods Mentioned

BETA
infrared spectroscopy
chemical modification

Software Mentioned

Spectrum
SPSS Statistics

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