Development of nanofiber-covered stents using electrospinning: in vitro and acute phase in vivo experiments

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Keita KuraishiWaro Taki

Abstract

There are some technical difficulties in treating for a broad necked aneurysm and a higher incidence of recurrence. Because of these drawbacks, more innovative techniques for superior endovascular reconstructive treatment are required. We developed a novel covered stent employing electrospinning to deposit fine polyurethane (PU) fibers onto stents. An in vitro water leak test was designed and applied prior to animal testing to estimate the performance of covered stents and to determine the appropriate amount of PU fibers on a stent. Two tenths of a milligram of PU fibers proved to be sufficient to prevent water leakage. Then, the efficacy of the covered stents to that of bare stents was compared using 10 rabbits in which model aneurysms had been formed at the right common carotid artery by the elastase method. Angiographic evaluation on day 1 posttreatment (acute phase) revealed complete occlusion of the aneurysms and the patency of the parent arteries in animals treated with covered stents. At 10 days poststenting (subacute phase), the aneurysm neck was completely covered with neointimal layer as shown by scanning electron microscopic examination. The PU-covered stent holds promise as a device for treating cerebral aneurysms.

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Citations

Jul 27, 2011·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Masaki MoriyamaHiroyuki Tonami
Nov 17, 2009·Pharmaceutical Research·Ravi Kumar NukalaDennis Douroumis
May 3, 2014·Nanomedicine·Hye Sung Kim, Hyuk Sang Yoo
Sep 27, 2013·Expert Opinion on Drug Delivery·Byeongtaek Oh, Chi H Lee
Dec 17, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Young Ju SonHyuk Sang Yoo
Apr 24, 2015·Journal of Neurointerventional Surgery·Waleed BrinjikjiRamanathan Kadirvel
Nov 1, 2016·Journal of Biomedical Materials Research. Part a·So-Youn LeeMyung Ho Jeong
Oct 13, 2018·Tissue Engineering. Part B, Reviews·Shigeo IchihashiPetra Mela
Jul 1, 2020·Neuroradiology·Haishuang TangQinghai Huang
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Dec 31, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Anandkumar NandakumarClemens van Blitterswijk

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